Biology:SGTA

Small glutamine-rich tetratricopeptide repeat-containing protein alpha is a protein that in humans is encoded by the SGTA gene. SGTA orthologs have also been identified in several mammals for which complete genome data are available. STGA belongs to a family of co-chaperone proteins that obtain a TPR motif. STGA was discovered just 15 years ago.

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Generic protein structure example

Function

The molecular function of the protein states that SGTA is a small glutamine-rich tetratricopeptide repeat (TRP)-containing protein, ubiquitously expressed, interacting with the NS1 protein of parvovirus H-1.

The SGTA gene encodes a protein that is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function.

Overview of main functions:

• hormone signaling
• viral assembly and release
• cell cycle and apoptosis
• intracellular compartmentalization
• neuronal synaptic transmission
• post-translational transport and modification of proteins.

Small glutamine-rich tetratricopeptide repeat-containing protein alpha (STGA) acts as a co-chaperone and regulator of androgen and growth hormone receptor signaling. The protein also mediates targets to the endoplasmic reticulum

Interactions

SGTA has been shown to interact with Growth hormone receptor.

Interacting Proteins for the SGTA Gene:

• HSPA4
• BAG6
• UBL4A
• HSPA8
• GET4

Associated Diseases

• Prostate, ovary, liver, and esophagus cancer
• Hormone-related polycystic ovary syndrome
• Amyloid-related Alzheimer's
• Prion Diseases

Further reading

• "Structural and Functional Insights into Small, Glutamine-Rich, Tetratricopeptide Repeat Protein Alpha". Frontiers in Molecular Biosciences 2: 71. Dec 2015. doi:10.3389/fmolb.2015.00071. PMID 26734616. 
• "Peptide analogs of thymopentin distinguish distinct thymopoietin receptor specificities on two human T cell lines". Regulatory Peptides 27 (2): 257–262. February 1990. doi:10.1016/0167-0115(90)90044-W. PMID 2158125. "Cell type-dependence for Vpu function". Journal of Medical Primatology 23 (2–3): 146–150. 1994. doi:10.1111/j.1600-0684.1994.tb00115.x. PMID 7966229. 
• "Identification of a novel cellular TPR-containing protein, SGT, that interacts with the nonstructural protein NS1 of parvovirus H-1". Journal of Virology 72 (5): 4149–4156. May 1998. doi:10.1128/JVI.72.5.4149-4156.1998. PMID 9557704. 
• "Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family". Journal of Virology 72 (6): 5189–5197. June 1998. doi:10.1128/JVI.72.6.5189-5197.1998. PMID 9573291. 
• "Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family". Journal of Virology 72 (10): 8461. October 1998. doi:10.1128/JVI.72.10.8460c-8460c.1998. PMID 9766974. 
• "Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats". The Journal of Biological Chemistry 274 (48): 34425–34432. November 1999. doi:10.1074/jbc.274.48.34425. PMID 10567422. 
• "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–1795. November 2000. doi:10.1101/gr.143000. PMID 11076863. 
• "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–435. March 2001. doi:10.1101/gr.GR1547R. PMID 11230166. 
• "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 (3): 287–292. September 2000. doi:10.1093/embo-reports/kvd058. PMID 11256614. 
• "Association of Vpu-binding protein with microtubules and Vpu-dependent redistribution of HIV-1 Gag protein". Virology 291 (2): 198–207. December 2001. doi:10.1006/viro.2001.1166. PMID 11878889. 
• "Small glutamine-rich protein/viral protein U-binding protein is a novel cochaperone that affects heat shock protein 70 activity". Cell Stress & Chaperones 7 (3): 258–268. July 2002. PMID 12482202. 
• "1H, 15N and 13C resonance assignments of the tetratricopeptide repeat (TPR) domain of hSGT". Journal of Biomolecular NMR 26 (4): 381–382. August 2003. doi:10.1023/A:1024029117511. PMID 12815268. 
• "hSGT interacts with the N-terminal region of myostatin". Biochemical and Biophysical Research Communications 311 (4): 877–883. November 2003. doi:10.1016/j.bbrc.2003.10.080. PMID 14623262. 
• "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics 83 (1): 153–167. January 2004. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819. 
• "The human small glutamine-rich TPR-containing protein is required for progress through cell division". Experimental Cell Research 293 (1): 43–57. February 2004. doi:10.1016/j.yexcr.2003.09.028. PMID 14729056. 
• "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–12135. August 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.