Biography:Michel C. Nussenzweig

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Short description: Brazilian immunologist
Michel C. Nussenzweig
Nussenzweig 2015.1446150841.jpg
Born (1955-02-10) February 10, 1955 (age 69)
São Paulo, Brazil
Education
  • The Rockefeller University (Ph.D., 1981)
  • New York University School of Medicine (M.D., 1982)
Alma materNew York University (B.A., 1975)
Spouse(s)Svetlana Mojsov
Scientific career
FieldsImmunology
Molecular Biology
InstitutionsThe Rockefeller University

Michel C. Nussenzweig (born February 10, 1955) is a professor and head of the Laboratory of Molecular Immunology at The Rockefeller University and a Howard Hughes Medical Institute investigator. He is a member of both the US National Academy of Medicine and the US National Academy of Sciences.

Education and career

Nussenzweig graduated summa cum laude with a B.A. degree from New York University College of Arts and Sciences in 1975. He earned a Ph.D. from The Rockefeller University in 1981 in cellular immunology, working in Zanvil A. Cohn’s laboratory with Ralph M. Steinman on groundbreaking studies of mouse dendritic cells.

As a Ph.D. student, Nussenzweig was the first to show that dendritic cells present foreign antigens to initiate T cell immunity.[1] He also produced the first dendritic cell-specific monoclonal antibody and cloned the first dendritic cell receptor.[2]

Nussenzweig received an M.D. from New York University School of Medicine in 1982 and completed his internship and residency in internal medicine, and a clinical fellowship in infectious diseases at Massachusetts General Hospital in 1985. From 1986 to 1989, he was a postdoctoral fellow in genetics in the Harvard Medical School laboratory of Philip Leder. Nussenzweig returned to The Rockefeller University as an assistant professor in 1990 and he became an associate professor in 1994, and a professor and senior physician in 1996. In 2013, he was named the first Zanvil A. Cohn and Ralph M. Steinman Professor.[3][4]

Summary of research achievements

Nussenzweig studies molecular aspects of the immune system’s adaptive and innate responses, using a combination of biochemistry, molecular biology, and genetics. Work on adaptive immunity focuses on B lymphocytes and antibodies to HIV-1, while work on innate immunity focuses on dendritic cells.[5] The laboratory has isolated and cloned human antibodies to HIV-1 and explored their roles in prevention and therapy. In clinical trials, a broadly neutralizing antibody isolated from an HIV-infected patient was shown to be safe and effective and to interfere with chronic infection in a way that traditional antiretroviral therapy does not.[6][7] His research has led to the development of innovative vaccines against infectious diseases and new treatments for autoimmunity.[8][9]

Awards and honors

  • American Association of Immunologists Meritorious Career Award, 2004[10]
  • American Academy of Arts and Sciences, 2007[11]
  • Lee C. Howley Sr. Prize for Arthritis Research, 2008[12]
  • National Academy of Medicine, 2009[13]
  • National Academy of Sciences, 2011[14]
  • Brazilian Academy of Sciences, 2011[15]
  • Nobel Prize Lecture on behalf of Ralph Steinman, 2011[16]
  • Brazil Diaspora Prize, 2015[17]
  • Spanish Royal Academy, 2016[18]
  • Rabbi Shai Shacknai Memorial Prize in Immunology and Cancer Research, 2016[19]
  • Robert Koch Award, 2016[20]
  • AAI-BioLegend Herzenberg Award, 2017[21]
  • Sanofi-Institut Pasteur Award, 2017[22]

References

  1. ↑ Nussenzweig, M. C.; Steinman, R. M. (1 May 1980). "Contribution of dendritic cells to stimulation of the murine syngeneic mixed leukocyte reaction" (in en). The Journal of Experimental Medicine 151 (5): 1196–1212. doi:10.1084/jem.151.5.1196. ISSN 0022-1007. PMID 6445399. 
  2. ↑ Nussenzweig, M C; Steinman, R M; Witmer, M D; Gutchinov, B (1 January 1982). "A monoclonal antibody specific for mouse dendritic cells". Proceedings of the National Academy of Sciences of the United States of America 79 (1): 161–165. doi:10.1073/pnas.79.1.161. ISSN 0027-8424. PMID 6948298. Bibcode: 1982PNAS...79..161N. 
  3. ↑ "Heads of Laboratory: Michel C. Nussenzweig". http://www.rockefeller.edu/research/faculty/labheads/MichelNussenzweig/#content. Retrieved 16 Aug 2016. 
  4. ↑ "Immunity and Tolerance". http://www.hhmi.org/research/immunity-and-tolerance. Retrieved 16 Aug 2016. 
  5. ↑ Scheid, Johannes F.; Mouquet, Hugo; Feldhahn, Niklas; Seaman, Michael S.; Velinzon, Klara; Pietzsch, John; Ott, Rene G.; Anthony, Robert M. et al. (2 April 2009). "Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals". Nature 458 (7238): 636–640. doi:10.1038/nature07930. PMID 19287373. Bibcode: 2009Natur.458..636S. 
  6. ↑ Halper-Stromberg, Ariel; Lu, Ching-Lan; Klein, Florian; Horwitz, Joshua A.; Bournazos, Stylianos; Nogueira, Lilian; Eisenreich, Thomas R.; Liu, Cassie et al. (28 August 2014). "Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice". Cell 158 (5): 989–999. doi:10.1016/j.cell.2014.07.043. PMID 25131989. 
  7. ↑ Scheid, Johannes F. (28 July 2016). "HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption". Nature 535 (7613): 556–560. doi:10.1038/nature18929. PMID 27338952. Bibcode: 2016Natur.535..556S. 
  8. ↑ Lu, Ching-Lan; Murakowski, Dariusz K.; Bournazos, Stylianos; Schoofs, Till; Sarkar, Debolina; Halper-Stromberg, Ariel; Horwitz, Joshua A.; Nogueira, Lilian et al. (20 May 2016). "Enhanced clearance of HIV-1–infected cells by broadly neutralizing antibodies against HIV-1 in vivo" (in en). Science 352 (6288): 1001–1004. doi:10.1126/science.aaf1279. ISSN 0036-8075. PMID 27199430. Bibcode: 2016Sci...352.1001L. 
  9. ↑ Schoofs, Till; Klein, Florian; Braunschweig, Malte; Kreider, Edward F.; Feldmann, Anna; Nogueira, Lilian; Oliveira, Thiago; Lorenzi, Julio C. C. et al. (20 May 2016). "HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1" (in en). Science 352 (6288): 997–1001. doi:10.1126/science.aaf0972. ISSN 0036-8075. PMID 27199429. Bibcode: 2016Sci...352..997S. 
  10. ↑ "AAI-Thermo Fisher Meritorious Career Award". http://www.aai.org/Awards/Archive/Meritorious.html. 
  11. ↑ "Twelve Howard Hughes Medical Institute Scientists Elected to American Academy of Arts and Sciences". http://www.hhmi.org/news/twelve-howard-hughes-medical-institute-scientists-elected-american-academy-arts-and-sciences. Retrieved 15 August 2016. 
  12. ↑ "Past Howley Prize Recipients". http://www.arthritis.org/arthritis-cure/for-researchers/howley-prize-for-arthritis-research/past-howley-prize-recipients.php. 
  13. ↑ "Institute of Medicine Elects 65 New Members, Five Foreign Associates". http://www8.nationalacademies.org/onpinews/newsitem.aspx?RecordID=10122009a. Retrieved 15 August 2016. 
  14. ↑ "Michel C. Nussenzweig elected to National Academy of Sciences". 3 May 2011. http://newswire.rockefeller.edu/?page=engine&id=1165. 
  15. ↑ "Eleitos novos membros da ABC" (in Portuguese). 16 December 2011. http://www.abc.org.br/article.php3?id_article=1768. 
  16. ↑ "Nobel Lecture 2011". https://www.nobelprize.org/prizes/medicine/2011/steinman/lecture/. Retrieved 18 September 2022. 
  17. ↑ "Prêmio Diáspora Brasil divulga vencedores" (in Portuguese). http://www.diasporabrasil.com.br/premio/sitepages/noticias.aspx?NoticiasID=4. 
  18. ↑ "Toma de Posesión de Académico de Honor del Excmo. Sr. D. Michel C. Nussenzweig" (in Spanish). 11 April 2016. http://www.ranf.com/sesiones-y-actos/recepciones/2216-academico-honor-michel-c-nussenzweig.html. 
  19. ↑ "The 2016 Rabbi Shai Shacknai Memorial Lecture in Immunology and Cancer Research". https://medicine.ekmd.huji.ac.il/He/Home/Lists/Events/Attachments/802/RabbiShacknaiMemorialLecture_05.06.2016.pdf. 
  20. ↑ "With their outstanding research, laureates lay the foundation for understanding the way in which different immunological mechanisms function". 22 June 2016. http://www.robert-koch-stiftung.de/index.php?article_id=300&clang=1. 
  21. ↑ "AAI-BioLegend Herzenberg Award Past Recipients". http://www.aai.org/Awards/Career-Awards/AAI-Herzenberg-Award/Past-Recipients.aspx. 
  22. ↑ "JEM Editorial Board Co-Chair wins 2017 Sanofi-Institut Pasteur Award". 12 December 2017. http://jem.rupress.org/announcement-2. 



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