Biology:Collagen, type IV, alpha 6
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Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
Collagen alpha-6(IV) chain is a protein that in humans is encoded by the COL4A6 gene.[1][2]
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Two splice variants have been identified for this gene.[2]
References
- ↑ "Deletion of the paired alpha 5(IV) and alpha 6(IV) collagen genes in inherited smooth muscle tumors". Science 261 (5125): 1167–9. Sep 1993. doi:10.1126/science.8356449. PMID 8356449. Bibcode: 1993Sci...261.1167Z.
- ↑ 2.0 2.1 "Entrez Gene: COL4A6 collagen, type IV, alpha 6". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1288.
Further reading
- "Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth". Cell Tissue Res. 296 (2): 221–7. 1999. doi:10.1007/s004410051283. PMID 10382266.
- "Corneal cell proteins and ocular surface pathology". Biotechnic & Histochemistry 74 (3): 146–59. 1999. doi:10.3109/10520299909047967. PMID 10416788.
- "Short amino acid sequences derived from C1q receptor (C1q-R) show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IV". J. Leukoc. Biol. 51 (6): 546–56. 1992. doi:10.1002/jlb.51.6.546. PMID 1377218.
- "Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface". Eur. J. Cell Biol. 56 (1): 58–67. 1992. PMID 1724753.
- "Extracellular matrix of the human optic nerve head". Am. J. Ophthalmol. 102 (2): 139–48. 1986. doi:10.1016/0002-9394(86)90134-0. PMID 2426947.
- "Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II". Histochemistry 82 (2): 149–58. 1985. doi:10.1007/bf00708199. PMID 3997552.
- "The localization and secretion of type IV collagen in synovial capillaries by immunohistochemistry using a monoclonal antibody against human type IV collagen". Exp. Cell Biol. 52 (3): 159–69. 1984. doi:10.1159/000163256. PMID 6386565.
- "Immunolocalization of collagen types, laminin and fibronectin in the normal human pancreas". Digestion 30 (3): 158–64. 1984. doi:10.1159/000199100. PMID 6389236.
- "Monoclonal antibody to human basement membrane collagen type IV". Immunology 47 (1): 133–40. 1982. PMID 6811420.
- "Distribution of basement membrane proteins in normal and fibrotic human liver: collagen type IV, laminin, and fibronectin". Gut 21 (1): 63–71. 1980. doi:10.1136/gut.21.1.63. PMID 6988303.
- "Binding of mouse and human fibulin-2 to extracellular matrix ligands". J. Mol. Biol. 254 (5): 892–9. 1996. doi:10.1006/jmbi.1995.0664. PMID 7500359.
- "Isolation and structure of the COL4A6 gene encoding the human alpha 6(IV) collagen chain and comparison with other type IV collagen genes". J. Biol. Chem. 270 (45): 26863–7. 1995. doi:10.1074/jbc.270.45.26863. PMID 7592929.
- "The genes COL4A5 and COL4A6, coding for basement membrane collagen chains alpha 5(IV) and alpha 6(IV), are located head-to-head in close proximity on human chromosome Xq22 and COL4A6 is transcribed from two alternative promoters". Proc. Natl. Acad. Sci. U.S.A. 91 (24): 11679–83. 1994. doi:10.1073/pnas.91.24.11679. PMID 7972123. Bibcode: 1994PNAS...9111679S.
- "Regulation of protease nexin-1 target protease specificity by collagen type IV". J. Biol. Chem. 269 (25): 17199–205. 1994. doi:10.1016/S0021-9258(17)32540-1. PMID 8006028.
- "Identification of a new collagen IV chain, alpha 6(IV), by cDNA isolation and assignment of the gene to chromosome Xq22, which is the same locus for COL4A5". J. Biol. Chem. 269 (10): 7520–6. 1994. doi:10.1016/S0021-9258(17)37317-9. PMID 8125972.
- "Complete primary structure of the sixth chain of human basement membrane collagen, alpha 6(IV). Isolation of the cDNAs for alpha 6(IV) and comparison with five other type IV collagen chains". J. Biol. Chem. 269 (18): 13193–9. 1994. doi:10.1016/S0021-9258(17)36818-7. PMID 8175748.
- "Structure of the human type IV collagen COL4A6 gene, which is mutated in Alport syndrome-associated leiomyomatosis". Genomics 33 (3): 473–9. 1996. doi:10.1006/geno.1996.0222. PMID 8661006.
- "Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans". J. Cell. Biochem. 65 (2): 145–58. 1997. doi:10.1002/(SICI)1097-4644(199705)65:2<145::AID-JCB2>3.0.CO;2-U. PMID 9136074.
- "Stimulation of extracellular matrix components in the normal brain by invading glioma cells". Int. J. Cancer 75 (6): 864–72. 1998. doi:10.1002/(SICI)1097-0215(19980316)75:6<864::AID-IJC8>3.0.CO;2-T. PMID 9506531.
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