Biology:HLA-DR5

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Illustration of HLA-DR

HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.

Serology

DR11, DR5 and DR12 recognition of the gene products of some DRB1*11 and DRB1*12 alleles[1]
DRB1* DR11 DR5 DR12 Sample
allele % % % size (N)
11:01 92 5 3474
11:02 89 3 430
11:03 89 4 397
11:04 87 4 2119
11:05 75 4
11:06 20 73 15
11:07 >50 1
11:08 >50 2
11:09 80 20 5
.
DR12 DR5 DR11 Sample
12:01 83 4 2 893 [2]
12:02 89 162
12:03 >50 3
12:06 >50 2

Except for a few DRB1* alleles, the reactivity of DR5 is relatively poor.

Disease associations

DR5 is associated with persistent generalized lymphadenopathy[3] and Kaposi's sarcoma in AIDS,[4] juvenile rheumatoid arthritis,[5][6] pernicious anemia, Hashimoto's thyroiditis,[7][8] mycosis fungoides,[9] polyglandular deficiency syndrome,[10] systemic sclerosis,[11][12] childhood epilepsy,[13] early-onset alopecia areata,[14] short-ragweed Ra6 allergy,[15] primary antiphospholipid syndrome,[16] and increased longevity in the Dutch.[17]

Genetic linkage

HLA-DR5 reactive gene products are linked to serology of HLA-DRB3 (HLA-DR52).

References

  1. derived from IMGT/HLA
  2. DR8 - 2%
  3. "HLA-A, B and DR antigen frequencies in patients with AIDS-related persistent generalized lymphadenopathy (PGL) and thrombocytopenia.". Tissue Antigens 29 (1): 60–2. 1987. doi:10.1111/j.1399-0039.1987.tb01550.x. PMID 3495904. 
  4. "Frequencies of HLA and Gm immunogenetic markers in Kaposi's sarcoma.". Tissue Antigens 21 (1): 1–8. 1983. doi:10.1111/j.1399-0039.1983.tb00364.x. PMID 6601312. 
  5. "HLA antigens in juvenile arthritis. Genetic basis for the different subtypes.". Arthritis Rheum 26 (1): 35–8. 1983. doi:10.1002/art.1780260106. PMID 6401993. 
  6. "HLA-DR5 in juvenile rheumatoid arthritis confined to few joints.". Lancet 2 (8184): 40. 1980. doi:10.1016/S0140-6736(80)92920-7. PMID 6104257. 
  7. "The association of goitrous autoimmune thyroiditis with HLA-DR5.". Tissue Antigens 17 (3): 265–8. 1981. doi:10.1111/j.1399-0039.1981.tb00700.x. PMID 6947505. 
  8. "HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter.". J Clin Endocrinol Metab 56 (4): 781–5. 1983. doi:10.1210/jcem-56-4-781. PMID 6131902. 
  9. "Association of HLA-DR5 with mycosis fungoides.". J Invest Dermatol 80 (5): 395–7. 1983. doi:10.1111/1523-1747.ep12553615. PMID 6601679. 
  10. "The polyglandular deficiency syndrome: a new variant in Persian Jews.". J Endocrinol Invest 10 (1): 1–7. 1987. doi:10.1007/bf03347139. PMID 3496374. 
  11. "Autoantibodies and immunogenetics in 30 patients with systemic sclerosis and their families.". J Rheumatol 14 (4): 760–5. 1987. PMID 3499513. 
  12. "Association of progressive systemic scleroderma to several HLA-B and HLA-DR alleles.". Arch Dermatol 123 (9): 1188–91. 1987. doi:10.1001/archderm.123.9.1188. PMID 3498440. 
  13. "On the association of the HLA system with epilepsy in children.". Epilepsia 28 (1): 74–6. 1987. doi:10.1111/j.1528-1157.1987.tb03626.x. PMID 3098558. 
  14. "Human leukocyte antigen region involvement in the genetic predisposition to alopecia areata.". Dermatologica 175 (1): 10–4. 1987. doi:10.1159/000248775. PMID 3497062. 
  15. "Immune responsiveness to Ambrosia artemisiifolia (short ragweed) pollen allergen Amb a VI (Ra6) is associated with HLA-DR5 in allergic humans.". Immunogenetics 26 (4–5): 230–6. 1987. doi:10.1007/BF00346517. PMID 3498688. 
  16. "Association of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients". Arthritis Rheum 38 (9): 1340–1. 1995. doi:10.1002/art.1780380925. PMID 7575732. 
  17. "Longevity and heredity in humans. Association with the human leucocyte antigen phenotype". Ann N Y Acad Sci 621: 78–89. 1991. doi:10.1111/j.1749-6632.1991.tb16970.x. PMID 1859103.