Biology:MAGEA12
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Melanoma-associated antigen 12 is a protein that in humans is encoded by the MAGEA12 gene.[1][2]
Function
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.[2]
References
- ↑ "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics 29 (3): 725–31. October 1995. doi:10.1006/geno.1995.9945. PMID 8575766.
- ↑ 2.0 2.1 "Entrez Gene: MAGEA12 melanoma antigen family A, 12". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4111.
Further reading
- "Structure, chromosomal localization, and expression of 12 genes of the MAGE family". Immunogenetics 40 (5): 360–9. 1994. doi:10.1007/BF01246677. PMID 7927540.
- "Cloning and analysis of MAGE-1-related genes". Biochemical and Biophysical Research Communications 202 (1): 549–55. July 1994. doi:10.1006/bbrc.1994.1963. PMID 8037761. https://zenodo.org/record/1229420.
- "Sequence and expression pattern of the human MAGE2 gene". Immunogenetics 39 (2): 121–9. 1994. doi:10.1007/bf00188615. PMID 8276455.
- "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man". Genome Research 10 (6): 758–75. June 2000. doi:10.1101/gr.10.6.758. PMID 10854409.
- "Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters". Molecular Cancer Research 5 (7): 749–59. July 2007. doi:10.1158/1541-7786.MCR-06-0364. PMID 17634428.
 |
