Biology:OS9 (gene)
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Protein OS-9 is a protein that in humans is encoded by the OS9 gene.[1][2][3][4][5]
Function
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[5]
References
- ↑ "Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas". Molecular Carcinogenesis 15 (4): 270–5. Apr 1996. doi:10.1002/(SICI)1098-2744(199604)15:4<270::AID-MC4>3.0.CO;2-K. PMID 8634085. https://zenodo.org/record/1235506.
- ↑ "Genomic organization of the OS-9 gene amplified in human sarcomas". Journal of Biochemistry 122 (6): 1190–5. Dec 1997. doi:10.1093/oxfordjournals.jbchem.a021880. PMID 9498564.
- ↑ "Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans". The Journal of Biological Chemistry 284 (25): 17061–8. Jun 2009. doi:10.1074/jbc.M809725200. PMID 19346256.
- ↑ "OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD". Nature Cell Biology 10 (3): 272–82. Mar 2008. doi:10.1038/ncb1689. PMID 18264092.
- ↑ 5.0 5.1 "Entrez Gene: OS9 amplified in osteosarcoma". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10956.
Further reading
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. Jan 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha". Molecular Cell 17 (4): 503–12. Feb 2005. doi:10.1016/j.molcel.2005.01.011. PMID 15721254.
- "Functional proteomics mapping of a human signaling pathway". Genome Research 14 (7): 1324–32. Jul 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "Identification of a new peptide recognized by autologous cytolytic T lymphocytes on a human melanoma". Cancer Immunity 2: 9. Jul 2002. PMID 12747754.
- "A selective interaction between OS-9 and the carboxyl-terminal tail of meprin beta". The Journal of Biological Chemistry 277 (37): 34413–23. Sep 2002. doi:10.1074/jbc.M203986200. PMID 12093806.
- "YOS9, the putative yeast homolog of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins". The Journal of Biological Chemistry 277 (38): 35274–81. Sep 2002. doi:10.1074/jbc.M201044200. PMID 12077121.
- "Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma". FEBS Letters 453 (1–2): 77–80. Jun 1999. doi:10.1016/S0014-5793(99)00700-0. PMID 10403379.
- "Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines". Journal of Biochemistry 123 (5): 876–82. May 1998. doi:10.1093/oxfordjournals.jbchem.a022019. PMID 9562620.
- "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers". Genomics 42 (2): 295–301. Jun 1997. doi:10.1006/geno.1997.4727. PMID 9192850. https://zenodo.org/record/1229731.
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