Biology:SMARCE1
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 Generic protein structure example |
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 is a protein that in humans is encoded by the SMARCE1 gene.[1][2]
Function
The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.[2]
Interactions
SMARCE1 has been shown to interact with Estrogen receptor alpha,[3] SMARCB1[4][5] and SMARCA4.[4][5]
References
- ↑ "Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes". Proceedings of the National Academy of Sciences of the United States of America 95 (2): 492–8. Jan 1998. doi:10.1073/pnas.95.2.492. PMID 9435219. Bibcode: 1998PNAS...95..492W.
- ↑ 2.0 2.1 "Entrez Gene: SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6605.
- ↑ "Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes". The EMBO Journal 21 (15): 4094–103. Aug 2002. doi:10.1093/emboj/cdf412. PMID 12145209.
- ↑ 4.0 4.1 "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". The EMBO Journal 15 (19): 5370–82. Oct 1996. doi:10.1002/j.1460-2075.1996.tb00921.x. PMID 8895581.
- ↑ 5.0 5.1 "Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling". Cell 95 (5): 625–36. Nov 1998. doi:10.1016/S0092-8674(00)81633-5. PMID 9845365.
Further reading
- "Recent advances in understanding chromatin remodeling by Swi/Snf complexes". Current Opinion in Genetics & Development 13 (2): 136–42. Apr 2003. doi:10.1016/S0959-437X(03)00022-4. PMID 12672490.
- "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". The EMBO Journal 15 (19): 5370–82. Oct 1996. doi:10.1002/j.1460-2075.1996.tb00921.x. PMID 8895581.
- "A human RNA polymerase II complex containing factors that modify chromatin structure". Molecular and Cellular Biology 18 (9): 5355–63. Sep 1998. doi:10.1128/MCB.18.9.5355. PMID 9710619.
- "Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits". Molecular Cell 3 (2): 247–53. Feb 1999. doi:10.1016/S1097-2765(00)80315-9. PMID 10078207.
- "The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes". Proceedings of the National Academy of Sciences of the United States of America 97 (24): 13015–20. Nov 2000. doi:10.1073/pnas.240208597. PMID 11078522. Bibcode: 2000PNAS...9713015X.
- "Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignancies". Journal of Cellular Physiology 186 (1): 136–45. Jan 2001. doi:10.1002/1097-4652(200101)186:1<136::AID-JCP1010>3.0.CO;2-4. PMID 11147808.
- "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 (3): 287–92. Sep 2000. doi:10.1093/embo-reports/kvd058. PMID 11256614.
- "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". The Journal of Biological Chemistry 277 (7): 5498–505. Feb 2002. doi:10.1074/jbc.M108702200. PMID 11734557.
- "Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes". Nature 418 (6894): 195–9. Jul 2002. doi:10.1038/nature00876. PMID 12110891.
- "Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes". The EMBO Journal 21 (15): 4094–103. Aug 2002. doi:10.1093/emboj/cdf412. PMID 12145209.
- "REST repression of neuronal genes requires components of the hSWI.SNF complex". The Journal of Biological Chemistry 277 (43): 41038–45. Oct 2002. doi:10.1074/jbc.M205691200. PMID 12192000.
- "Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter". The Journal of Biological Chemistry 278 (20): 17876–84. May 2003. doi:10.1074/jbc.M209480200. PMID 12637547.
- "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell 113 (7): 905–17. Jun 2003. doi:10.1016/S0092-8674(03)00436-7. PMID 12837248.
- "BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation". Molecular and Cellular Biology 23 (17): 6210–20. Sep 2003. doi:10.1128/MCB.23.17.6210-6220.2003. PMID 12917342.
- "Protein profile of tax-associated complexes". The Journal of Biological Chemistry 279 (1): 495–508. Jan 2004. doi:10.1074/jbc.M310069200. PMID 14530271.
- "Yeast two-hybrid screens implicate DISC1 in brain development and function". Biochemical and Biophysical Research Communications 311 (4): 1019–25. Nov 2003. doi:10.1016/j.bbrc.2003.10.101. PMID 14623284.
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