Biology:PHF2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

PHD finger protein 2 is a protein that in humans is encoded by the PHF2 gene.

Function

This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys₄-His-Cys₃ arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.

Further reading

• "Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma". Mol. Cancer 7: 84. 2008. doi:10.1186/1476-4598-7-84. PMID 18990233. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.