Biology:KLK2

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Kallikrein-2 is a protein that in humans is encoded by the KLK2 gene, and is particularly associated with prostatic tissue.[1][2][3][4]

References

  1. ↑ "The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19". FEBS Lett 247 (1): 123–126. May 1989. doi:10.1016/0014-5793(89)81253-0. PMID 2468530. 
  2. ↑ "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem 387 (6): 637–641. Jun 2006. doi:10.1515/BC.2006.082. PMID 16800724. https://epub.ub.uni-muenchen.de/17786/. 
  3. ↑ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem 387 (6): 635–636. doi:10.1515/BC.2006.081. PMID 16800723. 
  4. ↑ "Entrez Gene: KLK2 Kallikrein-related peptidase 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3817. 

Further reading

  • Riegman PH; Vlietstra RJ; van der Korput HA et al. (1992). "Identification and androgen-regulated expression of two major human glandular kallikrein-1 (hGK-1) mRNA species". Mol. Cell. Endocrinol. 76 (1–3): 181–190. doi:10.1016/0303-7207(91)90272-T. PMID 1726490. 
  • Qin H; Kemp J; Yip MY et al. (1992). "Localization of human glandular kallikrein-1 gene to chromosome 19q13.3-13.4 by in situ hybridization". Hum. Hered. 41 (4): 222–226. doi:10.1159/000154005. PMID 1783409. 
  • "Primary structure of a human glandular kallikrein gene". DNA 6 (5): 429–437. 1988. doi:10.1089/dna.1987.6.429. PMID 2824146. 
  • Frenette G; Deperthes D; Tremblay RR et al. (1997). "Purification of enzymatically active kallikrein hK2 from human seminal plasma". Biochim. Biophys. Acta 1334 (1): 109–15. doi:10.1016/s0304-4165(96)00080-3. PMID 9042371. 
  • Bourgeois L; Brillard-Bourdet M; Deperthes D et al. (1997). "Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2". J. Biol. Chem. 272 (47): 29590–29595. doi:10.1074/jbc.272.47.29590. PMID 9368023. 
  • "Human glandular kallikrein, hK2, shows arginine-restricted specificity and forms complexes with plasma protease inhibitors". Prostate 34 (1): 44–50. 1998. doi:10.1002/(SICI)1097-0045(19980101)34:1<44::AID-PROS6>3.0.CO;2-K. PMID 9428387. 
  • "Identification of the transcriptional regulatory sequences of human kallikrein 2 and their use in the construction of calydon virus 764, an attenuated replication competent adenovirus for prostate cancer therapy". Cancer Res. 59 (7): 1498–504. 1999. PMID 10197620. 
  • "Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1". Int. J. Cancer 81 (3): 438–442. 1999. doi:10.1002/(SICI)1097-0215(19990505)81:3<438::AID-IJC18>3.0.CO;2-U. PMID 10209959. 
  • Lövgren J; Valtonen-André C; Marsal K et al. (1999). "Measurement of prostate-specific antigen and human glandular kallikrein 2 in different body fluids". J. Androl. 20 (3): 348–55. PMID 10386814. 
  • Cargill M; Altshuler D; Ireland J et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes". Nat. Genet. 22 (3): 231–238. doi:10.1038/10290. PMID 10391209. 
  • "Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors". Eur. J. Biochem. 262 (3): 781–789. 1999. doi:10.1046/j.1432-1327.1999.00433.x. PMID 10411640. 
  • Mikolajczyk SD; Millar LS; Marker KM et al. (1999). "Identification of a novel complex between human kallikrein 2 and protease inhibitor-6 in prostate cancer tissue". Cancer Res. 59 (16): 3927–30. PMID 10463585. 
  • Liu XF; Essand M; Vasmatzis G et al. (1999). "Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing". Biochem. Biophys. Res. Commun. 264 (3): 833–839. doi:10.1006/bbrc.1999.1595. PMID 10544017. https://zenodo.org/record/1229510. 
  • Ren F; Zhang S; Mitchell SH et al. (2000). "Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells". Oncogene 19 (15): 1924–1932. doi:10.1038/sj.onc.1203511. PMID 10773882. 
  • Harvey TJ; Hooper JD; Myers SA et al. (2001). "Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4". J. Biol. Chem. 275 (48): 37397–37406. doi:10.1074/jbc.M004525200. PMID 10969073. 
  • "A positively charged loop on the surface of kallistatin functions to enhance tissue kallikrein inhibition by acting as a secondary binding site for kallikrein". J. Biol. Chem. 275 (51): 40371–40377. 2001. doi:10.1074/jbc.M005691200. PMID 10991942. 
  • Gan L; Lee I; Smith R et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene 257 (1): 119–130. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574. 
  • Réhault S; Monget P; Mazerbourg S et al. (2001). "Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3". Eur. J. Biochem. 268 (10): 2960–2968. doi:10.1046/j.1432-1327.2001.02185.x. PMID 11358513. 
  • Saedi MS; Zhu Z; Marker K et al. (2002). "Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells". Int. J. Cancer 94 (4): 558–563. doi:10.1002/ijc.1501. PMID 11745444. 

External links

  • The MEROPS online database for peptidases and their inhibitors: S01.161
  • Overview of all the structural information available in the PDB for UniProt: P20151 (Human Kallikrein-2) at the PDBe-KB.




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