Biology:DEFB105A
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Beta-defensin 105 is a protein that is encoded by the DEFB105A gene in humans.[1][2][3]
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: Alpha defensins, Beta defensins and Theta defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105A, represents the more centromeric copy.[3]
References
- ↑ "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A 99 (4): 2129–33. Feb 2002. doi:10.1073/pnas.042692699. PMID 11854508.
- ↑ "Duplication and selection in the evolution of primate beta-defensin genes". Genome Biol 4 (5): R31. May 2003. doi:10.1186/gb-2003-4-5-r31. PMID 12734011.
- ↑ 3.0 3.1 "Entrez Gene: DEFB105A defensin, beta 105A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=245908.
Further reading
- "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.". Physiol. Genomics 23 (1): 5–17. 2006. doi:10.1152/physiolgenomics.00104.2005. PMID 16033865.
- "Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution.". Genet. Test. 8 (3): 325–7. 2005. doi:10.1089/gte.2004.8.325. PMID 15727258.
- "Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence.". BMC Genomics 5 (1): 92. 2006. doi:10.1186/1471-2164-5-92. PMID 15588320.
- "Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster.". Am. J. Hum. Genet. 73 (3): 591–600. 2003. doi:10.1086/378157. PMID 12916016.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice.". J. Immunol. 169 (5): 2516–23. 2002. doi:10.4049/jimmunol.169.5.2516. PMID 12193721.
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