Biology:NEDD1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene and encodes the protein NEDD1.

NEDD1 is localized in the centrosome and it plays a role in mitosis through its interaction with γ-tubulin. WD40 repeats are located in the amino-terminal of the protein and are responsible for NEDD1 localization in the centrosome, and the carboxy-terminal amino acids are needed for interactions with γ-tubulin. Depletion of NEDD1 causes impaired centrosome and chromatin microtubules assembly that results in the failure of microtubule nucleation and prevents proper spindle formation.

Further reading

• "The role of NEDD1 phosphorylation by Aurora A in chromosomal microtubule nucleation and spindle function.". Curr. Biol. 23 (2): 143–9. 2012. doi:10.1016/j.cub.2012.11.046. PMID 23273898. 
• "Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome.". Curr. Biol. 22 (16): 1516–23. 2012. doi:10.1016/j.cub.2012.06.027. PMID 22818914. 
• "NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly.". J. Cell Biol. 172 (4): 505–15. 2006. doi:10.1083/jcb.200510028. PMID 16461362. 
• "GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation.". Nat. Cell Biol. 8 (2): 137–47. 2006. doi:10.1038/ncb1349. PMID 16378099. 
• "Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.". Mol. Endocrinol. 19 (10): 2451–65. 2005. doi:10.1210/me.2004-0476. PMID 16051665. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Assignment of the developmentally regulated gene NEDD1 to human chromosome 12q22 by fluorescence in situ hybridization.". Hum. Genet. 95 (1): 96–8. 1995. doi:10.1007/BF00225082. PMID 7814034.