Biology:COG3943 RNA motif
| COG3943 | |
|---|---|
 Consensus secondary structure and sequence conservation of COG3943 RNA | |
| Identifiers | |
| Symbol | COG3943 |
| Rfam | RF02941 |
| Other data | |
| RNA type | Gene; sRNA |
| SO | 0001263 |
| PDB structures | PDBe |
The COG3943 RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] COG3943 motifs are found in unknown bacteria whose genomic DNA was isolated from cow rumen. As of 2018, there is no specific, classified organism that is known to contain a COG3943 motif RNA.
It is ambiguous whether COG3943 RNAs function as cis-regulatory elements or whether they operate in trans. They are upstream of multiple different types of protein-coding genes, which would suggest that they function as cis regulators. However, in a few cases, the gene that is downstream of a COG3943 RNA is either located very far away or on the opposite DNA strand, and these cases tend to argue against a cis-regulatory function. Assuming that the RNA is cis regulatory, the genes that would be regulated by the RNAs lack specific functional annotations, which makes it difficult to develop a hypothesis for the RNA's function.
References
- ↑ "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. October 2017. doi:10.1093/nar/gkx699. PMID 28977401.
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