Biology:NASP (gene)
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Nuclear autoantigenic sperm protein is a protein that in humans is encoded by the NASP gene.[1][2] Multiple isoforms are encoded by transcript variants of this gene.
Function
This gene encodes a histone H1 binding protein that is involved in transporting histones into the nucleus of dividing cells.[3] The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa.[2]
References
- ↑ "Sequence and localization of human NASP: conservation of a Xenopus histone-binding protein". Dev Biol 154 (1): 37–44. Dec 1992. doi:10.1016/0012-1606(92)90045-I. PMID 1426632.
- ↑ 2.0 2.1 "Entrez Gene: NASP nuclear autoantigenic sperm protein (histone-binding)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4678.
- ↑ "Association of NASP with HSP90 in mouse spermatogenic cells: stimulation of ATPase activity and transport of linker histones into nuclei". J. Biol. Chem. 280 (4): 2904–11. January 2005. doi:10.1074/jbc.M410397200. PMID 15533935.
Further reading
- "Characterization of a sperm-specific nuclear autoantigenic protein. I. Complete sequence and homology with the Xenopus protein, N1/N2.". Biol. Reprod. 43 (4): 559–68. 1991. doi:10.1095/biolreprod43.4.559. PMID 2289010.
- "Characterization of a sperm-specific nuclear autoantigenic protein. II. Expression and localization in the testis.". Biol. Reprod. 43 (4): 569–78. 1991. doi:10.1095/biolreprod43.4.569. PMID 2289011.
- "Molecular characterization of a karyophilic, histone-binding protein: cDNA cloning, amino acid sequence and expression of nuclear protein N1/N2 of Xenopus laevis.". EMBO J. 5 (13): 3547–52. 1987. doi:10.1002/j.1460-2075.1986.tb04681.x. PMID 3549279.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Ultrastructural localization of a nuclear autoantigenic sperm protein in spermatogenic cells and spermatozoa". Anat. Rec. 236 (3): 442–8. 1993. doi:10.1002/ar.1092360304. PMID 8363049.
- "Histone-binding domains in a human nuclear autoantigenic sperm protein". Biol. Reprod. 54 (6): 1238–44. 1996. doi:10.1095/biolreprod54.6.1238. PMID 8724350.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Characterization of the histone H1-binding protein, NASP, as a cell cycle-regulated somatic protein". J. Biol. Chem. 275 (39): 30378–86. 2000. doi:10.1074/jbc.M003781200. PMID 10893414.
- "Analysis of the autoimmune epitopes on human testicular NASP using recombinant and synthetic peptides". Clin. Exp. Immunol. 121 (2): 201–9. 2000. doi:10.1046/j.1365-2249.2000.01303.x. PMID 10931132.
- "Analysis of gene expression in mouse 2-cell embryos using fluorescein differential display: comparison of culture environments". Biol. Reprod. 64 (1): 30–5. 2001. doi:10.1095/biolreprod64.1.30. PMID 11133655.
- "Comparison of mouse and human NASP genes and expression in human transformed and tumor cell lines". Gene 274 (1–2): 67–75. 2001. doi:10.1016/S0378-1119(01)00605-9. PMID 11674998.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Overexpression of the Linker histone-binding protein tNASP affects progression through the cell cycle". J. Biol. Chem. 278 (10): 8846–52. 2003. doi:10.1074/jbc.M210352200. PMID 12509435.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Generation of longer 3' cDNA fragments from massively parallel signature sequencing tags". Nucleic Acids Res. 32 (12): e94. 2004. doi:10.1093/nar/gnh095. PMID 15247327.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Human Asf1 regulates the flow of S phase histones during replicational stress". Mol. Cell 17 (2): 301–11. 2005. doi:10.1016/j.molcel.2004.12.018. PMID 15664198.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
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