Biology:SLC22A13

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Solute carrier family 22 member 13 is a protein that in humans is encoded by the SLC22A13 gene.

Function

This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine.

Further reading

• "Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)". J. Biol. Chem. 283 (24): 16332–41. 2008. doi:10.1074/jbc.M800737200. PMID 18411268. 
• "Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers". Cell Death Differ. 16 (6): 890–8. 2009. doi:10.1038/cdd.2009.21. PMID 19282870. 
• "The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin". Clin. Pharmacol. Ther. 86 (3): 299–306. 2009. doi:10.1038/clpt.2009.92. PMID 19536068. 
• "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. 2010. doi:10.2119/molmed.2009.00159. PMID 20379614. 
• "SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct". Biochem. J. 457 (2): 243–51. 2014. doi:10.1042/BJ20130654. PMID 24147638. 
• "The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis". Oncogene 34 (13): 1718–28. 2015. doi:10.1038/onc.2014.93. PMID 24769897. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.