Biology:PhIP-Seq

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Phage immunoprecipitation sequencing (PhIP-Seq) is method that combines barcoded DNA high-throughput sequencing and proteomics to determine the levels of binding of antibodies to epitopes. It has been used to study the autoantibody repertoire of autoimmune diseases like multiple sclerosis, type 2 diabetes and rheumatoid arthritis.[1][2]

References

  1. ↑ Larman, H (2011). "Autoantigen discovery with a synthetic human peptidome". Nature Biotechnology 29 (6): 535–541. doi:10.1038/nbt.1856. PMID 21602805. 
  2. ↑ Larman, H (June 2013). "PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis". Journal of Autoimmunity 43: 1–9. doi:10.1016/j.jaut.2013.01.013. PMID 23497938. 




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