Medicine:Nanoimpellers
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Nanoimpellers are an experimental technology developed to eliminate some of the harmful effects of chemotherapy by facilitating treatment of only specific areas of the body. Nanoimpellers are nanoscale, light-activated containers filled with cancer-fighting drugs that only release their contents when hit by a specific type of laser.[1] Nanoimpellers for cancer drug delivery were first demonstrated in 2008.[2][3] Initial work used ultraviolet light, however the low penetration in tissue and potential for toxicity mean this is not well suited for delivery in patients.[1] Later work has shifted to using near infrared light and two photon excitation (TPE) to trigger release.[4][5]
See also
References
- ↑ 1.0 1.1 Zheng, Yue Bing; Kiraly, Brian; Huang, Tony Jun (November 2010). "Molecular machines drive smart drug delivery". Nanomedicine 5 (9): 1309–1312. doi:10.2217/nnm.10.111. PMID 21128714.
- ↑ Lu, Jie; Choi, Eunshil; Tamanoi, Fuyuhiko; Zink, Jeffrey I. (31 March 2008). "Light-Activated Nanoimpeller-Controlled Drug Release in Cancer Cells". Small 4 (4): 421–426. doi:10.1002/smll.200700903. PMID 18383576.
- ↑ "Nanomachine Kills Cancer Cells With Exposure To Light". Inventorspot. 25 April 2008. http://inventorspot.com/articles/nanomachine_kills_cancer_cells_upon_light_exposure_13118. Retrieved 30 March 2015.
- ↑ Tian, He; Zhang, Junji (2016-06-14) (in en). Photochromic Materials: Preparation, Properties and Applications. John Wiley & Sons. p. 223. ISBN 9783527683703. https://books.google.com/books?id=x7tlDAAAQBAJ&pg=PA223.
- ↑ Croissant, Jonas; Maynadier, Marie; Gallud, Audrey; Peindy N'Dongo, Harmel; Nyalosaso, Jeff L.; Derrien, Gaëlle; Charnay, Clarence; Durand, Jean-Olivier et al. (16 December 2013). "Two-Photon-Triggered Drug Delivery in Cancer Cells Using Nanoimpellers". Angewandte Chemie International Edition 52 (51): 13813–13817. doi:10.1002/anie.201308647. PMID 24214916.
External links
- Bullock, Dave (6 May 2008). "A Little Hope for Cancer Treatment". Wired. Archived from the original on 25 October 2012. https://web.archive.org/web/20121025084418/https://www.wired.com/science/discoveries/multimedia/2008/06/gallery_nanocancer?slide=1&slideView=7.
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