Biology:SEC63
 Generic protein structure example |
Translocation protein SEC63 homolog is a protein that in humans is encoded by the SEC63 gene.[1][2][3]
Function
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.[3]
Clinical significance
Mutations of this gene have been linked with autosomal dominant polycystic liver disease.[4]
References
- ↑ "Human Sec63 endoplasmic reticulum membrane protein, map position 6q21". Chromosome Res 7 (1): 77. Jun 1999. doi:10.1023/A:1009283530544. PMID 10219736.
- ↑ "Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog". Biol Chem 380 (9): 1133–8. Nov 1999. doi:10.1515/BC.1999.142. PMID 10543453.
- ↑ 3.0 3.1 "Entrez Gene: SEC63 SEC63 homolog (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11231.
- ↑ "Mutations in SEC63 cause autosomal dominant polycystic liver disease". Nat. Genet. 36 (6): 575–7. June 2004. doi:10.1038/ng1357. PMID 15133510.
Further reading
- "Mammalian Sec61 is associated with Sec62 and Sec63.". J. Biol. Chem. 275 (19): 14550–7. 2000. doi:10.1074/jbc.275.19.14550. PMID 10799540.
- Ponting CP (2001). "Proteins of the endoplasmic-reticulum-associated degradation pathway: domain detection and function prediction.". Biochem. J.. 351 Pt 2: 527–35. PMID 11023840.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Mutations in SEC63 cause autosomal dominant polycystic liver disease.". Nat. Genet. 36 (6): 575–7. 2004. doi:10.1038/ng1357. PMID 15133510.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. 2007. doi:10.1093/dnares/12.2.117. PMID 16303743.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- "Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors.". PLOS Biol. 5 (5): e109. 2007. doi:10.1371/journal.pbio.0050109. PMID 17456004.
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