Biology:HBXIP
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 Generic protein structure example |
Hepatitis B virus X-interacting protein is a protein that in humans is encoded by the HBXIP gene.[1][2]
This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus.[2]
Interactions
HBXIP has been shown to interact with NCOA6.[3]
References
- ↑ "Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication". Journal of Virology 72 (3): 1737–43. March 1998. doi:10.1128/jvi.72.3.1737-1743.1998. PMID 9499022.
- ↑ 2.0 2.1 "Entrez Gene: HBXIP hepatitis B virus x interacting protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10542.
- ↑ "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology 38 (5): 1258–66. November 2003. doi:10.1053/jhep.2003.50451. PMID 14578865.
Further reading
- "Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription". The Journal of Biological Chemistry 277 (12): 9982–8. March 2002. doi:10.1074/jbc.M111354200. PMID 11788598.
- "Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells". World Journal of Gastroenterology 8 (2): 213–6. April 2002. doi:10.3748/wjg.v8.i2.213. PMID 11925594.
- "HBXIP functions as a cofactor of survivin in apoptosis suppression". The EMBO Journal 22 (11): 2729–40. June 2003. doi:10.1093/emboj/cdg263. PMID 12773388.
- "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology 38 (5): 1258–66. November 2003. doi:10.1053/jhep.2003.50451. PMID 14578865.
- "The hepatitis B virus X protein up-regulates lymphotoxin alpha expression in hepatocytes". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1741 (1–2): 75–84. June 2005. doi:10.1016/j.bbadis.2004.10.004. PMID 15955450.
- "The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage". The Journal of Biological Chemistry 280 (39): 33525–35. September 2005. doi:10.1074/jbc.M506628200. PMID 16055925.
- "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. September 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- "Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP". The FEBS Journal 272 (19): 5008–19. October 2005. doi:10.1111/j.1742-4658.2005.04910.x. PMID 16176273.
- "Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma". Journal of Hepatology 45 (6): 805–12. December 2006. doi:10.1016/j.jhep.2006.07.025. PMID 17050029. http://ousar.lib.okayama-u.ac.jp/11640.
- "Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress". Journal of Virology 81 (12): 6757–60. June 2007. doi:10.1128/JVI.00172-07. PMID 17428866.
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