Biology:GPSM2
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G-protein-signaling modulator 2, also called LGN for its 10 Leucine-Glycine-Asparagine repeats, is a protein that in humans is encoded by the GPSM2 gene.[1][2][3]
Function
Heterotrimeric G proteins transduce extracellular signals received by cell surface receptors into integrated cellular responses. GPSM2 belongs to a group of proteins that modulate activation of G proteins (Blumer et al., 2002).[supplied by OMIM][3]
Interactions
GPSM2 has been shown to interact with nuclear mitotic apparatus protein 1[4] and GNAI2.[2][5]
References
- ↑ "Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis". J. Biol. Chem. 277 (18): 15897–903. Apr 2002. doi:10.1074/jbc.M112185200. PMID 11832491.
- ↑ 2.0 2.1 "Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2". Gene 181 (1–2): 39–43. 1996. doi:10.1016/S0378-1119(96)00456-8. PMID 8973305.
- ↑ 3.0 3.1 "Entrez Gene: GPSM2 G-protein signalling modulator 2 (AGS3-like, C. elegans)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29899.
- ↑ "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. 3 (12): 1069–75. Dec 2001. doi:10.1038/ncb1201-1069. PMID 11781568.
- ↑ "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Mol. Cell. Biol. 23 (11): 3847–58. Jun 2003. doi:10.1128/MCB.23.11.3847-3858.2003. PMID 12748287.
Further reading
- "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. 3 (12): 1069–75. 2001. doi:10.1038/ncb1201-1069. PMID 11781568.
- "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Mol. Cell. Biol. 23 (11): 3847–58. 2003. doi:10.1128/MCB.23.11.3847-3858.2003. PMID 12748287.
- "Subcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progression". Mol. Biol. Cell 14 (8): 3144–55. 2003. doi:10.1091/mbc.E03-04-0212. PMID 12925752.
- "Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins". Cell 119 (4): 503–16. 2004. doi:10.1016/j.cell.2004.10.028. PMID 15537540.
- "Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division". J. Biol. Chem. 280 (8): 6761–5. 2005. doi:10.1074/jbc.C400440200. PMID 15632202.
- "Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population". J. Hypertens. 23 (8): 1497–505. 2005. doi:10.1097/01.hjh.0000174606.41651.ae. PMID 16003176.
- "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3". Biochem. Biophys. Res. Commun. 341 (4): 1001–6. 2006. doi:10.1016/j.bbrc.2006.01.050. PMID 16458856.
External links
- Overview of all the structural information available in the PDB for UniProt: P81274 (Human G-protein-signaling modulator 2) at the PDBe-KB.
- Overview of all the structural information available in the PDB for UniProt: Q8VDU0 (Mouse G-protein-signaling modulator 2) at the PDBe-KB.
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