Biology:AP4B1
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AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene.[1][2]
Function
The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1, this protein) and epsilon-4 (AP4E1), a medium chain, mu-4 (AP4M1), and a small chain, sigma-4 (AP4S1)[2]
Interactions
AP4B1 has been shown to interact with AP4M1.[3]
Clinical relevance
AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.[4][5]
References
- ↑ "AP-4, a novel protein complex related to clathrin adaptors". J Biol Chem 274 (11): 7278–85. Apr 1999. doi:10.1074/jbc.274.11.7278. PMID 10066790.
- ↑ 2.0 2.1 "Entrez Gene: AP4B1 adaptor-related protein complex 4, beta 1 subunit". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10717.
- ↑ "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell 10 (8): 2787–802. August 1999. doi:10.1091/mbc.10.8.2787. PMID 10436028.
- ↑ "Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature". Am. J. Hum. Genet. 88 (6): 788–95. June 2011. doi:10.1016/j.ajhg.2011.04.019. PMID 21620353.
- ↑ "Cerebral Palsy Linked to Genetic Abnormalities". medscape. https://www.medscape.com/viewarticle/759007.
External links
- Human AP4B1 genome location and AP4B1 gene details page in the UCSC Genome Browser.
- PDBe-KB provides an overview of all the structure information available in the PDB for Human AP-4 complex subunit beta-1
Further reading
- "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell 10 (8): 2787–802. 1999. doi:10.1091/mbc.10.8.2787. PMID 10436028.
- "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system". Biochem. Biophys. Res. Commun. 284 (4): 1083–9. 2001. doi:10.1006/bbrc.2001.5081. PMID 11409905.
- "The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1". Biochem. Biophys. Res. Commun. 298 (5): 720–30. 2003. doi:10.1016/S0006-291X(02)02522-6. PMID 12419313.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
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