Biology:EIF4G3

Generic protein structure example

Eukaryotic translation initiation factor 4 gamma 3 is a protein that in humans is encoded by the EIF4G3 gene. The gene encodes a protein that functions in translation by aiding the assembly of the ribosome onto the messenger RNA template. Confusingly, this protein is usually referred to as eIF4GII, as although EIF4G3 is the third gene that is similar to eukaryotic translation initiation factor 4 gamma, the second isoform EIF4G2 is not an active translation initiation factor.

Interactions

EIF4G3 has been shown to interact with PABPC1.

Further reading

• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation". EMBO J. 17 (24): 7480–9. 1998. doi:10.1093/emboj/17.24.7480. PMID 9857202. 
• "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". EMBO J. 18 (1): 270–9. 1999. doi:10.1093/emboj/18.1.270. PMID 9878069. 
• "Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo". Mol. Cell. Biol. 19 (3): 1871–80. 1999. doi:10.1128/MCB.19.3.1871. PMID 10022874. 
• "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. Bibcode: 2000PNAS...97.3491D. 
• "A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery". Mol. Cell 7 (1): 193–203. 2001. doi:10.1016/S1097-2765(01)00167-8. PMID 11172724. 
• "Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different". J. Virol. 77 (8): 5026–9. 2003. doi:10.1128/JVI.77.8.5026-5029.2003. PMID 12663812. 
• "Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII". J. Biomol. NMR 27 (3): 279–80. 2003. doi:10.1023/A:1025442322316. PMID 12975586. 
• "Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I". J. Biol. Chem. 278 (49): 48570–9. 2003. doi:10.1074/jbc.M308781200. PMID 14507913. 
• "Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro". J. Virol. 78 (7): 3271–8. 2004. doi:10.1128/JVI.78.7.3271-3278.2004. PMID 15016848. 
• "eIF4G is required for the pioneer round of translation in mammalian cells". Nat. Struct. Mol. Biol. 11 (10): 992–1000. 2004. doi:10.1038/nsmb824. PMID 15361857. 
• "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
• "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. 2006. doi:10.1038/nbt1240. PMID 16964243. 
• "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.