Biology:Asporin

Generic protein structure example

Asporin is a protein that in humans is encoded by the ASPN gene.

Function

ASPN belongs to a family of leucine-rich repeat (LRR) proteins associated with the cartilage matrix. The name asporin reflects the unique aspartate-rich N terminus and the overall similarity to decorin (MIM 125255) (Lorenzo et al., 2001).

External links

• Human ASPN genome location and ASPN gene details page in the UCSC Genome Browser.

Further reading

• "Identification and characterization of asporin. a novel member of the leucine-rich repeat protein family closely related to decorin and biglycan". The Journal of Biological Chemistry 276 (15): 12201–11. Apr 2001. doi:10.1074/jbc.M010932200. PMID 11152692. 
• "Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family". The Journal of Biological Chemistry 276 (15): 12212–21. Apr 2001. doi:10.1074/jbc.M011290200. PMID 11152695. 
• "Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene". Gene 275 (2): 279–86. Sep 2001. doi:10.1016/S0378-1119(01)00683-7. PMID 11587855. 
• "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research 13 (10): 2265–70. Oct 2003. doi:10.1101/gr.1293003. PMID 12975309. 
• "An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis". Nature Genetics 37 (2): 138–44. Feb 2005. doi:10.1038/ng1496. PMID 15640800. 
• "Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians". Arthritis Research & Therapy 8 (3): R55. 2006. doi:10.1186/ar1920. PMID 16542493. 
• "Regulation of PLAP-1 expression in periodontal ligament cells". Journal of Dental Research 85 (5): 447–51. May 2006. doi:10.1177/154405910608500510. PMID 16632759. 
• "Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese". Journal of Human Genetics 51 (12): 1068–72. 2007. doi:10.1007/s10038-006-0065-6. PMID 17024313. 
• "Meta-analysis of association between the ASPN D-repeat and osteoarthritis". Human Molecular Genetics 16 (14): 1676–81. Jul 2007. doi:10.1093/hmg/ddm115. PMID 17517696. 
• "Association of the aspartic acid-repeat polymorphism in the asporin gene with age at onset of knee osteoarthritis in Han Chinese population". Journal of Human Genetics 52 (8): 664–7. 2007. doi:10.1007/s10038-007-0166-x. PMID 17603749. 
• "Expression and regulation of the osteoarthritis-associated protein asporin". The Journal of Biological Chemistry 282 (44): 32193–9. Nov 2007. doi:10.1074/jbc.M706262200. PMID 17804408. 
• "Mechanisms for asporin function and regulation in articular cartilage". The Journal of Biological Chemistry 282 (44): 32185–92. Nov 2007. doi:10.1074/jbc.M700522200. PMID 17827158.