Biology:CELA2B
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Chymotrypsin-like elastase family member 2B is and enzyme that in humans is encoded by the CELA2B gene.[1][2][3]
Function
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues.[3]
References
- ↑ "Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas". DNA 6 (2): 163–72. April 1987. doi:10.1089/dna.1987.6.163. PMID 3646943.
- ↑ "Inactivity of Recombinant ELA2B Provides a New Example of Evolutionary Elastase Silencing in Humans". Pancreatology 6 (1–2): 117–22. 2006. doi:10.1159/000090031. PMID 16327289.
- ↑ 3.0 3.1 "Entrez Gene: chymotrypsin-like elastase family". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51032.
External links
- Human CELA2B genome location and CELA2B gene details page in the UCSC Genome Browser.
Further reading
- "Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA". Biochemistry 26 (23): 7256–61. 1987. doi:10.1021/bi00397a010. PMID 3427074.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity". Occup Environ Med 66 (12): 848–53. 2009. doi:10.1136/oem.2008.044024. PMID 19773279.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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