Medicine:Ketolysis

Ketolysis is the process of catabolizing ketones, the opposite of ketogenesis which is the process of synthesizing ketones. Ketogenesis occurs primarily in the liver, whereas ketolysis occurs in non-liver cells, especially in the heart, brain, and skeletal muscle. The SCOT enzyme is required for ketolysis, and is present in the mitochondria of all mammalian cells except for hepatocytes. The cardioprotective effects of SGLT2 inhibitors have been attributed to the elevated ketone levels and increased ketolysis.