Biology:Quadruple-stranded DNA

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• Biology:G-quadruplex

A quadruple-stranded DNA, also known as a G-quadruplex, is a package-like structure of DNA, formed by the interaction of four guanine bases that together make a square. Guanine, one of the chemical bases that make up DNA molecules, seems to be closely linked to DNA replication and cell division. Because of this, the G-quadruplex DNA may play a role in the development of cancer. Shankar Balasubramanian and his colleagues believe their discovery may help make it possible to stop the runaway cell proliferation at the root of cancer.

Shankar Balasubramanian in front of a mural in his office representing quadruplex DNA, called ‘Living by the code’ by artist Annie Newman.