Biography:Annette Herscovics
Annette Herscovics | |
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| Born | 1938 Paris, France |
| Died | September 6, 2008 Montreal, Canada |
| Alma mater |
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| Children | Philippe Herscovics |
| Awards | Fellow of the Royal Society of Canada |
| Scientific career | |
| Fields | Glycobiology |
| Institutions |
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Annette Herscovics (1938–2008) was a scientist at McGill University, a Fellow of the Royal Society of Canada, and a pioneer in the field of glycobiology.[1]
Personal life
Herscovics was born in Paris, France, the daughter of Polish Jews. She survived the Holocaust as a hidden child in Nazi-occupied France.[2][3] After immigrating to Canada , she obtained a PhD in biochemistry at McGill University in Montreal in 1963.[2]
Herscovics died of cancer on September 6, 2008.[3]
Career
Herscovics worked in the Department of Anatomy at McGill from 1967–1971, during which she made several important discoveries in glycobiology.[3] She discovered in 1969 that thyroglobulin undergoes carbohydrate modifications, part of a class of proteins known as glycoproteins.[4]
After completing her post-doctoral work at McGill, Herscovics moved to Harvard Medical School in 1971, where she remained until 1981. During this time she published more than 20 original papers in her field.[3]
In 1981, Herscovics returned to McGill University as an associate professor in the McGill Cancer Centre. She was appointed a professor in the Departments of Medicine and Biochemistry in 1987, and a professor in the Department of Oncology in 1992.[3] During this time she made several other important discoveries, including how the carbohydrate modifications are relevant to disease, including cancer.[4]
Herscovics was elected as a Fellow of the Royal Society of Canada in 1998.[2][3] She has published 110 peer-reviewed papers during her academic career.[3]
Published works
- Herscovics, Annette, and Peter Orlean. "Glycoprotein biosynthesis in yeast." The FASEB Journal 7.6 (1993): 540-550.
- Hosokawa, Nobuko, et al. "A novel ER α‐mannosidase‐like protein accelerates ER‐associated degradation." EMBO Reports 2.5 (2001): 415-422.
- Moremen, Kelley, Robert B. Trimble, and Annetté Herscovics. "Glycosidases of the asparagine-linked oligosaccharide processing pathway." Glycobiology 4.2 (1994): 113-125.
- Herscovics, Annette. "Importance of glycosidases in mammalian glycoprotein biosynthesis." Biochimica et Biophysica Acta (BBA)-General Subjects 1473.1 (1999): 96-107.
- Whur, P., Annette Herscovics, and C. P. Leblond. "Radioautographic visualization of the incorporation of galactose-3H and mannose-3H by rat thyroids in vitro in relation to the stages of thyroglobulin synthesis." The Journal of cell biology 43.2 (1969): 289-311.
- Herscovics, Annette. "Processing glycosidases of Saccharomyces cerevisiae." Biochimica et Biophysica Acta (BBA)-General Subjects 1426.2 (1999): 275-285.
References
- ↑ "Annette Herscovics". https://www.thecanadianencyclopedia.ca/en/article/annette-herscovics.
- ↑ 2.0 2.1 2.2 "Professor Annette Herscovics: 1938-2008" (in en-US). 2008-09-24. https://reporter.mcgill.ca/professor-annette-herscovics-1938-2008/.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Schachter, Harry (2009-06-01). "Obituary: Annette Herscovics (1938–2008)" (in en). Glycobiology 19 (6): 562–563. doi:10.1093/glycob/cwp033. ISSN 0959-6658. https://academic.oup.com/glycob/article/19/6/562/1987973.
- ↑ 4.0 4.1 "Canada's Unsung Female Heroes of Life Sciences" (in en). https://www.iisd.org/blog/canadas-unsung-female-heroes-life-sciences.
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