View source for Biology:(R)-3-amino-2-methylpropionate—pyruvate transaminase

{{Short description|Class of enzymes}}
{{infobox enzyme
| Name       = (R)-3-amino-2-methylpropionate-pyruvate transaminase
| EC_number  = 2.6.1.40
| CAS_number = 37279-00-8
| GO_code    = 0047305
| image      =
| width      = 
| caption    =  
}}

In [[Biology:Enzymology|enzymology]], a '''(R)-3-amino-2-methylpropionate—pyruvate transaminase''' ({{EC number|2.6.1.40}}) is an [[Biology:Enzyme|enzyme]] that [[Chemistry:Catalysis|catalyzes]] the [[Chemistry:Chemical reaction|chemical reaction]]

:(R)-3-amino-2-methylpropanoate + pyruvate <math>\rightleftharpoons</math> 2-methyl-3-oxopropanoate + L-alanine

Thus, the two [[Biology:Substrate (biochemistry)|substrates]] of this enzyme are (R)-3-amino-2-methylpropanoate and pyruvate, whereas its two [[Chemistry:Product|products]] are 2-methyl-3-oxopropanoate and L-alanine.

This enzyme belongs to the family of [[Biology:Transferase|transferase]]s, specifically the transaminases, which transfer nitrogenous groups.  The [[Biology:List of enzymes|systematic name]] of this enzyme class is '''(R)-3-amino-2-methylpropanoate:pyruvate aminotransferase'''. Other names in common use include '''D-3-aminoisobutyrate-pyruvate transaminase''', '''beta-aminoisobutyrate-pyruvate aminotransferase''', '''D-3-aminoisobutyrate-pyruvate aminotransferase''', '''D-3-aminoisobutyrate-pyruvate transaminase''', '''(R)-3-amino-2-methylpropionate transaminase''', and '''D-beta-aminoisobutyrate:pyruvate aminotransferase'''. But some additional information is that this enzyme catalyzed it transamination with L isomer, but D isomer in natural form, inactive as substrate. Also other names of enzymes similar to this contains, L-3-aminoisobutyrate transaminase, beta-aminobutyric transaminase, L-3-aminoisobutyric aminotransferase, and beta-aminoisobutyrate-alpha-ketoglutarate transaminase.<ref>"Kakimoto Y, Kanazawa A, Taniguchi K, Sano I (1968), and Tamaki N, Sakata SF, Matsuda K (2000)</ref>

==References==
{{reflist|1}}
* {{cite journal |vauthors=Kakimoto Y, Taniguchi K, Sano I | year = 1969 | title = D-beta-aminoisobutyrate:pyruvate aminotransferase in mammalian liver and excretion of beta-aminoisobutyrate by man | journal = J. Biol. Chem.  | volume = 244 | pages = 335&ndash;40  | pmid = 5773299 | issue = 2 }}
* {{cite journal |vauthors=Tamaki N, Sakata SF, Matsuda K | year = 2000 | title = Purification, properties, and sequencing of aminoisobutyrate aminotransferases from rat liver | journal = Methods Enzymol.  | volume = 324 | pages = 376&ndash;89  | pmid = 10989446 | doi = 10.1016/S0076-6879(00)24247-X | series = Methods in Enzymology | isbn = 9780121822255 }}

{{Nitrogenous transferases}}
{{Enzymes}}

{{DEFAULTSORT:(R)-3-amino-2-methylpropionate-pyruvate transaminase}}
[[Category:EC 2.6.1]]
[[Category:Enzymes of unknown structure]]



{{Sourceattribution|(R)-3-amino-2-methylpropionate—pyruvate transaminase}}