View source for Biology:3,4-dihydroxy-2-butanone-4-phosphate synthase

{{Short description|Class of enzymes}}
{{Infobox protein family
| Symbol = DHBP_synthase
| Name = DHBP_synthase
| image = PDB 1g58 EBI.jpg
| width = 
| caption = crystal structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase gold derivative
| Pfam = PF00926
| Pfam_clan =  
| InterPro = IPR000422
| SMART = 
| PROSITE = 
| MEROPS = 
| SCOP = 1iez
| TCDB = 
| OPM family = 
| OPM protein = 
| CAZy = 
| CDD = 
}}
The [[Biology:Enzyme|enzyme]] '''3,4-dihydroxy-2-butanone 4-phosphate synthase''' (DHBP synthase) (RibB) {{EnzExplorer|4.1.99.12}} [[Chemistry:Catalysis|catalyses]] the conversion of [[Chemistry:Ribulose 5-phosphate|D-ribulose 5-phosphate]] to [[Chemistry:Formate|formate]] and 3,4-dihydroxy-2-butanone 4-phosphate, the latter serving as the biosynthetic precursor for the [[Chemistry:Xylene|xylene]] ring of [[Biology:Riboflavin|riboflavin]].<ref name="pmid9211332">{{cite book | vauthors = Richter G, Krieger C, Volk R, Kis K, Ritz H, Götze E, Bacher A | title = Vitamins and Coenzymes Part J | chapter = Biosynthesis of riboflavin: 3,4-dihydroxy-2-butanone-4-phosphate synthase | series = Methods in Enzymology | volume = 280 | pages = 374–82 | year = 1997 | pmid = 9211332 | doi = 10.1016/S0076-6879(97)80128-0 | isbn = 9780121821814 }}</ref> In ''Photobacterium leiognathi'', the riboflavin synthesis genes ribB (DHBP synthase), ribE ([[Biology:Riboflavin synthase|riboflavin synthase]]), ribH ([[Biology:Lumazine synthase|lumazine synthase]]) and ribA ([[Biology:GTP cyclohydrolase II|GTP cyclohydrolase II]]) all reside in the lux [[Biology:Operon|operon]].<ref name="pmid11396941">{{cite journal | vauthors = Lin JW, Chao YF, Weng SF | title = Riboflavin synthesis genes ribE, ribB, ribH, ribA reside in the lux operon of Photobacterium leiognathi | journal = Biochemical and Biophysical Research Communications | volume = 284 | issue = 3 | pages = 587–95 | date = June 2001 | pmid = 11396941 | doi = 10.1006/bbrc.2001.5013 }}</ref> RibB is sometimes found as a bifunctional [[Biology:Enzyme|enzyme]] with [[Biology:GTP cyclohydrolase II|GTP cyclohydrolase II]] that catalyses the first committed step in the [[Biology:Biosynthesis|biosynthesis]] of riboflavin. No [[Biology:Sequence|sequence]]s with significant [[Biology:Homology|homology]] to DHBP synthase are found in the metazoa.

== References ==
{{reflist}}
{{InterPro content|IPR000422}}

{{Carbon-carbon lyases}}

[[Category:Protein families]]

{{Sourceattribution|3,4-dihydroxy-2-butanone-4-phosphate synthase}}