Biology:ATPase Domain 3B
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| ATAD3B | |
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| Gene Location (Human) File:Ideogram human chromosome 1.svg |
ATPase Domain 3B (ATAD3B) is a protein that in humans is encoded by the ATAD3B gene. [citation needed] ATAD3 is part of the AAA protein family. The function of ATAD3B is not yet well understood by the scientific community. In humans the gene is located at 1p36.33.
Function
ATAD3B is associated with the mitochondria. The C terminus is anchored in the mitochondrial inter membrane space.[1]
The protein is linked with the pluripotency of stem cells. The ATAD3A gene is targeted by c-Myc[1] which is one of four factors needed to create induced pluripotent stem (i-PS) cells from mouse embryonic fibroblasts(MEFs).[2]
Its expression is linked to cell cycle function and tumor growth.[3] When ATAD3B was overexpressed, cell duplication took an extra three hours by spending a longer time in G1 phase.[3] Abnormal expression levels of ATAD3B has been linked to chemoresistance. Overexpression of ATAD3B was the found to be the strongest factor in breast cancer survival rates.[4]
Characteristics
A mutation in the stop codon means that ATAD3B has a 62 amino acid longer UTR.[5]
References
- ↑ 1.0 1.1 Merle, Nicolas; Féraud, Olivier; Gilquin, Benoit; Hubstenberger, Arnaud; Kieffer-Jacquinot, Sylvie; Assard, Nicole; Bennaceur-Griscelli, Annelise; Honnorat, Jérôme et al. (2012-07-01). "ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A" (in en). Mitochondrion 12 (4): 441–448. doi:10.1016/j.mito.2012.05.005. ISSN 1567-7249. PMID 22664726. http://www.sciencedirect.com/science/article/pii/S1567724912000694.
- ↑ Takahashi, Kazutoshi; Yamanaka, Shinya (2006-08-25). "Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors" (in English). Cell 126 (4): 663–676. doi:10.1016/j.cell.2006.07.024. ISSN 0092-8674. PMID 16904174.
- ↑ 3.0 3.1 Hubstenberger, Arnaud; Labourdette, Gérard; Baudier, Jacques; Rousseau, Denis (2008-09-10). "ATAD 3A and ATAD 3B are distal 1p-located genes differentially expressed in human glioma cell lines and present in vitro anti-oncogenic and chemoresistant properties" (in en). Experimental Cell Research 314 (15): 2870–2883. doi:10.1016/j.yexcr.2008.06.017. ISSN 0014-4827. PMID 18639545. http://www.sciencedirect.com/science/article/pii/S0014482708002498.
- ↑ Ovaska, Kristian; Matarese, Filomena; Grote, Korbinian; Charapitsa, Iryna; Cervera, Alejandra; Liu, Chengyu; Reid, George; Seifert, Martin et al. (2013-06-20). Tucker-Kellogg, Greg. ed. "Integrative Analysis of Deep Sequencing Data Identifies Estrogen Receptor Early Response Genes and Links ATAD3B to Poor Survival in Breast Cancer" (in en). PLOS Computational Biology 9 (6): e1003100. doi:10.1371/journal.pcbi.1003100. ISSN 1553-7358. PMID 23818839. Bibcode: 2013PLSCB...9E3100O.
- ↑ Li, Shuijie; Rousseau, Denis (2012). "ATAD3, a vital membrane bound mitochondrial ATPase involved in tumor progression" (in en). Journal of Bioenergetics and Biomembranes 44 (1): 189–197. doi:10.1007/s10863-012-9424-5. ISSN 0145-479X. PMID 22318359.
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