Biology:HLA-DR5
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Illustration of HLA-DR
HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.
Serology
| DRB1* | DR11 | DR5 | DR12 | Sample |
| allele | % | % | % | size (N) |
| 11:01 | 92 | 5 | 3474 | |
| 11:02 | 89 | 3 | 430 | |
| 11:03 | 89 | 4 | 397 | |
| 11:04 | 87 | 4 | 2119 | |
| 11:05 | 75 | 4 | ||
| 11:06 | 20 | 73 | 15 | |
| 11:07 | >50 | 1 | ||
| 11:08 | >50 | 2 | ||
| 11:09 | 80 | 20 | 5 | |
| . | ||||
| DR12 | DR5 | DR11 | Sample | |
| 12:01 | 83 | 4 | 2 | 893 [2] |
| 12:02 | 89 | 162 | ||
| 12:03 | >50 | 3 | ||
| 12:06 | >50 | 2 |
Except for a few DRB1* alleles, the reactivity of DR5 is relatively poor.
Disease associations
DR5 is associated with persistent generalized lymphadenopathy[3] and Kaposi's sarcoma in AIDS,[4] juvenile rheumatoid arthritis,[5][6] pernicious anemia, Hashimoto's thyroiditis,[7][8] mycosis fungoides,[9] polyglandular deficiency syndrome,[10] systemic sclerosis,[11][12] childhood epilepsy,[13] early-onset alopecia areata,[14] short-ragweed Ra6 allergy,[15] primary antiphospholipid syndrome,[16] and increased longevity in the Dutch.[17]
Genetic linkage
HLA-DR5 reactive gene products are linked to serology of HLA-DRB3 (HLA-DR52).
References
- ↑ derived from IMGT/HLA
- ↑ DR8 - 2%
- ↑ "HLA-A, B and DR antigen frequencies in patients with AIDS-related persistent generalized lymphadenopathy (PGL) and thrombocytopenia.". Tissue Antigens 29 (1): 60–2. 1987. doi:10.1111/j.1399-0039.1987.tb01550.x. PMID 3495904.
- ↑ "Frequencies of HLA and Gm immunogenetic markers in Kaposi's sarcoma.". Tissue Antigens 21 (1): 1–8. 1983. doi:10.1111/j.1399-0039.1983.tb00364.x. PMID 6601312.
- ↑ "HLA antigens in juvenile arthritis. Genetic basis for the different subtypes.". Arthritis Rheum 26 (1): 35–8. 1983. doi:10.1002/art.1780260106. PMID 6401993.
- ↑ "HLA-DR5 in juvenile rheumatoid arthritis confined to few joints.". Lancet 2 (8184): 40. 1980. doi:10.1016/S0140-6736(80)92920-7. PMID 6104257.
- ↑ "The association of goitrous autoimmune thyroiditis with HLA-DR5.". Tissue Antigens 17 (3): 265–8. 1981. doi:10.1111/j.1399-0039.1981.tb00700.x. PMID 6947505.
- ↑ "HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter.". J Clin Endocrinol Metab 56 (4): 781–5. 1983. doi:10.1210/jcem-56-4-781. PMID 6131902.
- ↑ "Association of HLA-DR5 with mycosis fungoides.". J Invest Dermatol 80 (5): 395–7. 1983. doi:10.1111/1523-1747.ep12553615. PMID 6601679.
- ↑ "The polyglandular deficiency syndrome: a new variant in Persian Jews.". J Endocrinol Invest 10 (1): 1–7. 1987. doi:10.1007/bf03347139. PMID 3496374.
- ↑ "Autoantibodies and immunogenetics in 30 patients with systemic sclerosis and their families.". J Rheumatol 14 (4): 760–5. 1987. PMID 3499513.
- ↑ "Association of progressive systemic scleroderma to several HLA-B and HLA-DR alleles.". Arch Dermatol 123 (9): 1188–91. 1987. doi:10.1001/archderm.123.9.1188. PMID 3498440.
- ↑ "On the association of the HLA system with epilepsy in children.". Epilepsia 28 (1): 74–6. 1987. doi:10.1111/j.1528-1157.1987.tb03626.x. PMID 3098558.
- ↑ "Human leukocyte antigen region involvement in the genetic predisposition to alopecia areata.". Dermatologica 175 (1): 10–4. 1987. doi:10.1159/000248775. PMID 3497062.
- ↑ "Immune responsiveness to Ambrosia artemisiifolia (short ragweed) pollen allergen Amb a VI (Ra6) is associated with HLA-DR5 in allergic humans.". Immunogenetics 26 (4–5): 230–6. 1987. doi:10.1007/BF00346517. PMID 3498688.
- ↑ "Association of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients". Arthritis Rheum 38 (9): 1340–1. 1995. doi:10.1002/art.1780380925. PMID 7575732.
- ↑ "Longevity and heredity in humans. Association with the human leucocyte antigen phenotype". Ann N Y Acad Sci 621: 78–89. 1991. doi:10.1111/j.1749-6632.1991.tb16970.x. PMID 1859103.
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