View source for Biology:Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

{{Infobox enzyme
| Name       = Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
| EC_number  = 2.5.1.83
| CAS_number =
| GO_code    = 
| image      = 
| width      = 
| caption    =  
}}
'''Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)''' ({{EC number|2.5.1.83}}, ''HexPS'', ''hexaprenyl pyrophosphate synthetase'', ''hexaprenyl diphosphate synthase'') is an [[Biology:Enzyme|enzyme]] with [[Biology:List of enzymes|systematic name]] ''(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units)''.<ref>{{cite journal | vauthors = Fujii H, Koyama T, Ogura K | title = Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components | journal = The Journal of Biological Chemistry | volume = 257 | issue = 24 | pages = 14610–2 | date = December 1982 | doi = 10.1016/S0021-9258(18)33320-9 | pmid = 7174655 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Shimizu N, Koyama T, Ogura K | title = Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase | journal = Journal of Bacteriology | volume = 180 | issue = 6 | pages = 1578–81 | date = March 1998 | doi = 10.1128/JB.180.6.1578-1581.1998 | pmid = 9515931 | pmc = 107062 }}</ref><ref>{{cite journal | vauthors = Nagaki M, Kimura K, Kimura H, Maki Y, Goto E, Nishino T, Koyama T | title = Artificial substrates of medium-chain elongating enzymes, hexaprenyl- and heptaprenyl diphosphate synthases | journal = Bioorganic & Medicinal Chemistry Letters | volume = 11 | issue = 16 | pages = 2157–9 | date = August 2001 | pmid = 11514159 | doi = 10.1016/S0960-894X(01)00391-2 }}</ref> This enzyme [[Chemistry:Catalysis|catalyses]] the following [[Chemistry:Chemical reaction|chemical reaction]]

: (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate <math>\rightleftharpoons</math> 3 diphosphate + all-trans-hexaprenyl diphosphate

The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate.

== References ==
{{reflist}}

== External links ==
*{{MeshName|Hexaprenyl-diphosphate+synthase+((2E,6E)-farnesyl-diphosphate+specific)}}

{{Alkyl and aryl transferases}}
{{Enzymes}}

[[Category:EC 2.5.1]]

{{Sourceattribution|Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)}}