Biology:Interferon-induced transmembrane protein 2
 Generic protein structure example |
Interferon-induced transmembrane protein 2 is a protein that in humans is encoded by the IFITM2 gene.[1] IFITM1 is a member of the IFITM family (Interferon-induced transmembrane protein) which is encoded by IFITM genes.
As the name implies, these genes are induced by interferon and form part of its signaling pathway. In the absence of interferon stimulation, IFITM proteins can express broadly in tissues and cell lines. In humans, IFITM1, IFITM2 and IFITM3 are able to express in different tissues and cells while the expression of IFITM5 is limited to osteoblasts.[2]
Antiviral function
IFITM proteins have been identified as antiviral restriction factors that block the early stages of viral replication.[3] They inhibit influenza A virus replication,[4] and infection with a wide range of other enveloped viruses[5]
References
- ↑ "Entrez Gene: Interferon induced transmembrane protein 2". https://www.ncbi.nlm.nih.gov/gene/10581. Retrieved 2016-02-21.
- ↑ "IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion". Dev. Cell 9 (6): 745–56. December 2005. doi:10.1016/j.devcel.2005.10.010. PMID 16326387.
- ↑ "IFITM proteins restrict viral membrane hemifusion". PLOS Pathog. 9 (1): e1003124. January 2013. doi:10.1371/journal.ppat.1003124. PMID 23358889.
- ↑ "IFITM3 inhibits influenza A virus infection by preventing cytosolic entry". PLOS Pathog. 7 (10): e1002337. October 2011. doi:10.1371/journal.ppat.1002337. PMID 22046135.
- ↑ "The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus". Cell 139 (7): 1243–54. December 2009. doi:10.1016/j.cell.2009.12.017. PMID 20064371.
Further reading
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