Biology:BTBD1
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BTB/POZ domain-containing protein 1 is a protein that in humans is encoded by the BTBD1 gene.[1]
Function
The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. Alternative splicing results in multiple transcript variants encoding different isoforms.[1]
Interactions
BTBD1 has been shown to interact with TOP1.[2]
References
- ↑ 1.0 1.1 "Entrez Gene: BTBD1 BTB (POZ) domain containing 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53339.
- ↑ "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I". BMC Genomics 3: 1. 2002. doi:10.1186/1471-2164-3-1. PMID 11818025.
External links
- Human BTBD1 genome location and BTBD1 gene details page in the UCSC Genome Browser.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. Jan 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. Oct 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America 97 (7): 3491–6. Mar 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. Bibcode: 2000PNAS...97.3491D.
- "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. November 2000. doi:10.1101/gr.143000. PMID 11076863.
- "Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24". Gene 262 (1–2): 275–81. Jan 2001. doi:10.1016/S0378-1119(00)00513-8. PMID 11179693.
- "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. March 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 (3): 287–92. September 2000. doi:10.1093/embo-reports/kvd058. PMID 11256614.
- "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I". BMC Genomics 3: 1. 2003. doi:10.1186/1471-2164-3-1. PMID 11818025.
- "BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta". Experimental Cell Research 288 (1): 84–93. August 2003. doi:10.1016/S0014-4827(03)00187-3. PMID 12878161.
- "The topoisomerase 1-interacting protein BTBD1 is essential for muscle cell differentiation". Cell Death and Differentiation 11 (11): 1157–65. November 2004. doi:10.1038/sj.cdd.4401479. PMID 15486563. https://hal.archives-ouvertes.fr/hal-03219817/file/CDD%20version040504.pdf.
- "From ORFeome to biology: a functional genomics pipeline". Genome Research 14 (10B): 2136–44. Oct 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "The LIFEdb database in 2006". Nucleic Acids Research 34 (Database issue): D415–8. Jan 2006. doi:10.1093/nar/gkj139. PMID 16381901.
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