View source for Biology:N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase

{{Infobox enzyme
| Name       = N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
| EC_number  = 2.8.2.33
| CAS_number = 242469-38-1
| GO_code    =
| image      = 
| width      = 
| caption    =  
}}
'''N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase''' ({{EC number|2.8.2.33}}, ''GalNAc4S-6ST'', ''CHST15 (gene)'') is an [[Biology:Enzyme|enzyme]] with [[Biology:List of enzymes|systematic name]] ''3'-phosphoadenylyl-sulfate:(dermatan)-4-O-sulfo-N-acetyl-D-galactosamine 6-O-sulfotransferase''.<ref>{{cite journal | vauthors = Ito Y, Habuchi O | title = Purification and characterization of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase from the squid cartilage | journal = The Journal of Biological Chemistry | volume = 275 | issue = 44 | pages = 34728–36 | date = November 2000 | pmid = 10871629 | doi = 10.1074/jbc.M909633199 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Ohtake S, Ito Y, Fukuta M, Habuchi O | title = Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is related to human B cell recombination activating gene-associated gene | journal = The Journal of Biological Chemistry | volume = 276 | issue = 47 | pages = 43894–900 | date = November 2001 | pmid = 11572857 | doi = 10.1074/jbc.M104922200 | doi-access = free }}</ref> This enzyme [[Chemistry:Catalysis|catalyses]] the following [[Chemistry:Chemical reaction|chemical reaction]]

: (1) 3-phospho-5-adenylyl sulfate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine <math>\rightleftharpoons</math> adenosine 3',5'-bisphosphate + [dermatan]-4,6-di-O-sulfo-N-acetyl-D-galactosamine
: (2) 3-phospho-5-adenylyl sulfate + [chondroitin]-4-O-sulfo-N-acetyl-D-galactosamine <math>\rightleftharpoons</math> adenosine 3',5'-bisphosphate + [chondroitin]-4,6-di-O-sulfo-N-acetyl-D-galactosamine

The enzyme is activated by divalent cations and reduced [[Chemistry:Glutathione|glutathione]].

==Human proteins containing this domain==
*CHST15

== References ==
{{reflist}}

== External links ==
* {{MeshName|N-acetylgalactosamine+4-sulfate+6-O-sulfotransferase}}

{{Sulfur-containing group transferases}}
{{Enzymes}}

[[Category:EC 2.8.2]]

{{Sourceattribution|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase}}