Medicine:Drug vectorization
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Short description: Molecular targeting technique using nanoparticles or liposomes carrying adsorbed drug substances
In pharmacology and medicine, vectorization of drugs refers to (intracellular) targeting with plastic, noble metal or silicon nanoparticles or liposomes to which pharmacologically active substances are reversibly bound or attached by adsorption.[1][2]
CNRS researchers have devised a way to overcome the problem of multidrug resistance using polyalkyl cyanoacrylate (PACA) nanoparticles as "vectors".[3]
As a developing concept, drug nanocarriers are expected to play a major role in delivering multiple drugs to tumor tissues by overcoming semi-permeable membranes and biological barriers such as the blood–brain barrier.[4]
References
- ↑ Couvreur P. (2001). "Drug vectorization or how to modulate tissular and cellular distribution of biologically active compounds". Ann Pharm Fr 59 (4): 232–8. PMID 11468577.
- ↑ Secret, Emilie; Smith, Kevin; Dubljevic, Valentina; Moore, Eli; Macardle, Peter et al. (2012-11-30). "Antibody-Functionalized Porous Silicon Nanoparticles for Vectorization of Hydrophobic Drugs". Advanced Healthcare Materials (Wiley) 2 (5): 718–727. doi:10.1002/adhm.201200335. ISSN 2192-2640. PMID 23203914. https://unisa.alma.exlibrisgroup.com/view/delivery/61USOUTHAUS_INST/12143169470001831.
- ↑ "CNRSinfo - en380a6". http://www.cnrs.fr/Cnrspresse/en380a6.htm.
- ↑ Su, Chia-Wei; Chiang, Chih-Sheng; Li, Wei-Ming; Hu, Shang-Hsiu; Chen, San-Yuan (2014). "Multifunctional nanocarriers for simultaneous encapsulation of hydrophobic and hydrophilic drugs in cancer treatment". Nanomedicine (Lond.) 9 (10): 1499–515. doi:10.2217/nnm.14.97. PMID 25253498.
See also
- Vector (molecular biology)
- Cancer treatment
- Nanomedicine
- Nanobiotechnology
- Paul Ehrlich
- Gold nanobeacons
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