Biography:Alexander van Oudenaarden

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Short description: Dutch biophysicist and systems biologist
Alexander van Oudenaarden
VanOudenaarden2017a.jpg
Alexander van Oudenaarden (2017)
Born (1970-03-19) 19 March 1970 (age 54)
Zuidland, The Netherlands
CitizenshipKingdom of The Netherlands
Alma materDelft University of Technology (MSc, MSc, PhD)
Scientific career
FieldsBiophysics, Systems biology, Synthetic biology
InstitutionsHubrecht Institute

Alexander van Oudenaarden (19 March 1970) is a Dutch biophysicist and systems biologist. He is a leading researcher in stem cell biology, specialising in single cell techniques. In 2012 he started as director of the Hubrecht Institute and was awarded three times an ERC Advanced Grant, in 2012, 2017, and 2022. He was awarded the Spinoza Prize in 2017.

Biography

Van Oudenaarden was born 19 March 1970, in Zuidland, a small town in the Dutch province of South Holland. He studied at the Delft University of Technology, where he obtained an MSc degree in Materials Science and Engineering (cum laude) and an MSc degree in Physics, both in 1993, and subsequently a PhD degree in Physics (cum laude) in 1998 in experimental condensed matter physics, under the supervision of professor J.E. Mooij. He received the Andries Miedema Award (best doctoral research in the field of condensed matter physics in the Netherlands) for his thesis on "Quantum vortices and quantum interference effects in circuits of small tunnel junctions". In 1998, he moved to Stanford University, where he was a postdoctoral researcher in the departments of Biochemistry and of Microbiology & Immunology, working on force generation of polymerising actin filaments in the Theriot lab and a postdoctoral researcher in the department of Chemistry, working on Micropatterning of supported phospholipid bi-layers in the Boxer lab. In 2000 he joined the department of Physics at MIT as an assistant professor, was tenured in 2004 and became a full professor. In 2001 he received the NSF CAREER award, and was both an Alfred Sloan Research Fellow and the Keck Career Development Career Development Professor in Biomedical Engineering. In 2012 Alexander became the director of the Hubrecht Institute as the successor of Hans Clevers. In 2017 he received his second ERC Advanced Grant, for his study titled "a single-cell genomics approach integrating gene expression, lineage, and physical interactions". In 2022 he received his third ERC Advanced Grant, titled "scTranslatomics".[1]

In 2014 van Oudenaarden became a member of the Royal Netherlands Academy of Arts and Sciences.[2] In 2017 he was one of four winners of the Spinoza Prize.[3] In 2022 he was elected to the American Academy of Arts and Sciences (International Honorary Member).[4]

He is married and has three children.

Work

During his time at MIT his lab started with parallel lines of research in actin dynamics[5][6] and noise in gene networks,[7][8][9] and then focused on stochasticity in gene networks[10][11][12][13] biological networks as control systems,[14][15][16] and the evolution of small networks.

Today, Van Oudenaardens work at the Hubrecht Institute focuses on stochastic gene expression,[17][18] developing new tools for quantifying gene expression in single cells [19][20] and MicroRNAs [21][22]

References

  1. ↑ "List of Principal Investigators – All domains". https://erc.europa.eu/sites/default/files/document/file/erc-2021-adg-results-all-domains.pdf. 
  2. ↑ "Alexander van Oudenaarden". Royal Netherlands Academy of Arts and Sciences. https://www.knaw.nl/en/members/members/11404. 
  3. ↑ "Prof. dr. ir. A. (Alexander) van Oudenaarden". Netherlands Organisation for Scientific Research. https://www.nwo.nl/en/prof-dr-ir-alexander-van-oudenaarden. 
  4. ↑ "Alexander van Oudenaarden". 12 October 2023. https://www.amacad.org/person/alexander-van-oudenaarden. 
  5. ↑ Upadhyaya, A; Chabot, J. R.; Andreeva, A.; Samadani, A.; van Oudenaarden, A. (2003). "Probing polymerization forces by using actin-propelled lipid vesicles". PNAS USA 100 (8): 4521–6. doi:10.1073/pnas.0837027100. PMID 12657740. Bibcode: 2003PNAS..100.4521U. 
  6. ↑ Upadhyaya, A; A. van Oudenaarden (2003). "Biomimetic systems for studying actin-based motility". Current Biology 13 (18): R734–44. doi:10.1016/j.cub.2003.08.051. PMID 13678615. 
  7. ↑ Thattai, M; A. van Oudenaarden (2001). "Intrinsic noise in gene regulatory networks". PNAS USA 98 (15): 8614–9. doi:10.1073/pnas.151588598. PMID 11438714. Bibcode: 2001PNAS...98.8614T. 
  8. ↑ Ozbudak, E.; Thattai, M.; Kurtser, I.; Grossman, A. D.; van Oudenaarden, A. (2002). "Regulation of noise in the expression of a single gene". Nature Genetics 31 (1): 69–73. doi:10.1038/ng869. PMID 11967532. 
  9. ↑ Thattai, M; A. van Oudenaarden (2002). "Attenuation of noise in ultrasensitive signaling cascades". Biophysical Journal 82 (6): 2943–50. doi:10.1016/S0006-3495(02)75635-X. PMID 12023217. Bibcode: 2002BpJ....82.2943T. 
  10. ↑ Pedraza, J M; A. van Oudenaarden (2005). "Noise propagation in gene networks". Science 307 (5717): 1965–9. doi:10.1126/science.1109090. PMID 15790857. Bibcode: 2005Sci...307.1965P. 
  11. ↑ Becskei, A; B. B. Kaufmann; A. van Oudenaarden (2005). "Contributions of low molecule number and chromosomal positioning to stochastic gene expression". Nature Genetics 37 (9): 937–44. doi:10.1038/ng1616. PMID 16086016. 
  12. ↑ Acar, M; A. Becskei; A. van Oudenaarden (2005). "Enhancement of cellular memory by reducing stochastic transitions". Nature 435 (7039): 228–32. doi:10.1038/nature03524. PMID 15889097. Bibcode: 2005Natur.435..228A. 
  13. ↑ Chabot, J R; J. M. Pedraza; P. Luitel; A. van Oudenaarden (2007). "Stochastic gene expression out-of-steady-state in the cyanobacterial circadian clock". Nature 450 (7173): 1249–52. doi:10.1038/nature06395. PMID 18097413. Bibcode: 2007Natur.450.1249C. 
  14. ↑ Thattai, M; A. Becskei; A. van Oudenaarden (2005). "A system of counteracting feedback loops regulates Cdc42p activity during spontaneous cell polarization". Developmental Cell 9 (4): 565–71. doi:10.1016/j.devcel.2005.08.014. PMID 16198298. 
  15. ↑ Tsang, J; J. Zhu; A. van Oudenaarden (2007). "MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals". Molecular Cell 26 (5): 753–67. doi:10.1016/j.molcel.2007.05.018. PMID 17560377. 
  16. ↑ Mettetal, J; D. Muzzey; C. Gomez-Uribe; A. van Oudenaarden (2008). "The frequency dependence of osmo-adaptation in Saccharomyces cerevisiae". Science 319 (5862): 482–4. doi:10.1126/science.1151582. PMID 18218902. Bibcode: 2008Sci...319..482M. 
  17. ↑ Junker, Philipp; Alexander (2014). "Every cell is special: genome-wide studies add a new dimension to single-cell biology". Cell 157 (1): 8–11. doi:10.1016/j.cell.2014.02.010. PMID 24679522. 
  18. ↑ Ji, Ni; Middelkoop, Teije; Mentink, Remco; Betist, Marco; Tonegawa, Satto; Mooijman, Dylan; Korswagen, Hendrik; Alexander (2013). "Feedback control of gene expression variability in the Caenorhabditis elegans Wnt pathway". Cell 155 (4): 869–880. doi:10.1016/j.cell.2013.09.060. PMID 24209624. 
  19. ↑ Grün, Dominic; Kester, Lennart; Alexander (2014). "Validation of noise models for single-cell transcriptomics". Nature Methods 11 (6): 637–640. doi:10.1038/nmeth.2930. PMID 24747814. 
  20. ↑ Klemm, Sandy; Semrau, Stefan; Wiebrands, Kay; Mooijman, Dylan; Faddah, Dina; Jaenisch, Rudolf; Alexander (2014). "Transcriptional profiling of cells sorted by RNA abundance". Nature Methods 11 (5): 549–551. doi:10.1038/nmeth.2910. PMID 24681693. 
  21. ↑ Dong; Kim, Dominic Grün; Alexander (2013). "Dampening of expression oscillations by synchronous regulation of a microRNA and its target". Nature Genetics 45 (11): 1337–1344. doi:10.1038/ng.2763. PMID 24036951. 
  22. ↑ Mukherji, Shankar; Ebert, Margaret; Zheng, Grace; Tsang, John; Sharp, Phil; Alexander (2011). "MicroRNAs can generate thresholds in target gene expression". Nature Genetics 43 (9): 854–859. doi:10.1038/ng.905. PMID 21857679. PMC 3163764. http://dspace.mit.edu/bitstream/1721.1/74623/1/Sharp_MicroRNAs%20can.pdf. 

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