Biography:Cheng-Ming Chuong

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Cheng Ming Chuong
鍾正明
Born (1952-09-15) September 15, 1952 (age 73)
Taipei, Taiwan
CitizenshipAmerican
Alma materNational Taiwan University (MD)
Rockefeller University (PhD)
Scientific career
FieldsBiomedical science
InstitutionsUniversity of Southern California

Cheng-Ming Chuong (Chinese: 鍾正明; born 1952) is a Taiwanese-American physician-scientist specializing in biomedical science.[1] He is a professor of pathology in University of Southern California, and academician of Academia Sinica in Taiwan.[1]

Early life and education

Chuong grew up in Taipei, Taiwan, and attended medical school at National Taiwan University and graduated with a Doctor of Medicine (M.D.) in 1978.[2] He then completed doctoral studies in the United States at Rockefeller University, studying neural cell adhesion molecules and pattern formation with Gerald M. Edelman.[2] He earned his Ph.D. in developmental biology and molecular biology in 1983, and stayed as an assistant professor in the Rockefeller University till 1987.[2] With Edelman, he worked on identifying neural cell adhesion molecules and pattern formation in the brain.[3]

Career and research

He moved to the University of Southern California in 1987 and is currently a professor.[1] Chuong directs the Laboratory of Tissue Development and Engineering in the Department of Pathology, USC.[2] Using skin appendages as the experimental model, his team has studied how skin appendages undergo cyclic renewal and how these progenitor cells are guided to form specific tissue patterns and organ architectures in development, regeneration and evolution.[4] The research of his laboratory has been supported by National Institute of Health since 1988.[4][5]

He uses skin appendages as an experimental model and studies their organizing principles.[2] He has particularly focused on feather morphogenesis.[1] In 1998, he edited a book on "Epithelial Appendage Morphogenesis: Variations of a common theme and implications in regeneration".[5] In 2003, he edited a special issue on the evolution and development of Integument with Dominique G. Homberger.[6] In 2009, he edited another special issue with Michael K. Richardson on Pattern Formation.[7] In 2016, he published an essay on "The Tao of integuments" in Science.[8] He is mostly notable for:

Tissue patterning in the developing skin. In 1998, Chuong's laboratory showed how FGF/BMP fulfills Turing activator / inhibitor criteria in feather periodic pattern formation.[9] In 1999, they demonstrated self-organizing process in skin explants using dissociated dermal cells.[10] They further showed the assembly of dermal muscle network via mechanical force to build complex tissue patterning in the skin.[11]

Building region-specific feathers. Chuong's laboratory set up a model to study feather follicle which allows them to identify feather stem cells and molecular circuits involved in forming radially symmetric, bilaterally symmetric, and bilaterally asymmetric feathers, as well as barb branch types (feather vane vs fluffy branches) from the proximal to distal feather.[12] In 2019, they publish a comprehensive paper on the bio-architecture and adaptation of flight feathers.[10] In addition to feather forms, they demonstrate melanocyte stem cells in feather follicles and how they form within-a-feather color patterns and how beta keratin gene clusters use a novel strategy for gene cluster regulation.[13][14]

Reveal collective regenerative behavior in a hair follicle population. Chuong's team demonstrated intra-dermal adipose tissue exhibits BMP cycling which is out of phase with epidermal beta-catenin cycling in hair follicles.[15] Further, the intra-dermal adipose BMP remains high during pregnancy and lactation to maintain hairs for nursing.[16] These findings led to the concept that the extra-follicular macro-environment such as hormones, seasons, aging, can also modulate hair follicle stem cell activity.[17] They developed Cellular Automata model to describe this temporal patterning process.[18] Based on these, with topologically well-positioned hair plucking, they demonstrated an organ level quorum sensing process which can be hair regeneration more than those plucked.[19] Furthermore, they showed that tissue rigidity is involved in wound induced follicle neogenesis and can be modulated to enhance Turing periodic patterning process for de novo hair regeneration.[20] With these achievements, they are able to build reconstituted skin from dissociated progenitor cells for regenerative engineering.[10][21]

Evo-Devo of integumentary organs. In addition to the micro-evolution, which is the modification of organ shape, size, such as those seen in feathers, beaks, or tooth, Chuong's team worked on the macro-evolution mechanisms by converting scales into feathers.[22] They demonstrated the different regenerative mechanism of three different integumentary follicle types, hair, feather, and tooth.[23] Chuong also works with paleontologists on Mesozoic feathers.[24] The "Birth of Birds" was chosen as one of the 10 breakthroughs in 2014 by Science.[25]

Honors and awards

1988: American Cancer Society Junior Faculty Research Award[26]

1991: Robert Cleland Teaching Award[27]


1994: Robert Cleland Teaching Award, University of Southern California[27]

2000: John Ebbling Lecture, European Hair Research Society[28]

2002: Don Orwin Lecture, Australia[27]

2004: Riken symposium, Japan[27]

2006: Associates Award for Creativity in Research, Univ. Southern California[29]

2006: Saxén Medal awardee, Sigrid Juselius International Symposium, Finland[27]

2008: Elected to Academician, Academia Sinica, Taiwan (Taiwan National Academy)[4]

2013: Keynote, Japan Developmental Biology Society[27]

2014: Keynote, Korea Soc. Invest. Dermatology[27]

2014: A review contributing to "Birth of birds" as one of the 10 breakthroughs by Science[30]

2015: Elected to American Association for the Advancement of Science as a fellow[31]

2016: Kligman/Frost Leadership Award, Soc. Investigative Dermatology[32]

2018: Keynote, American Hair Research Summit[33]

2018: Keynote, Taiwan Society for Developmental Biology[34]

2020: NIH R37 MERIT award status, "Tissue patterning in living skin and explant cultures"[35]

2021: Plenary talk, Am Association for Anatomy, annual meeting in Exp. Biology

Chuong has served as associated editors and in editorial boards in major developmental biology and dermatology journals.[36][37] His grant on tissue patterning is awarded MERIT status in 2020.[4]

He became honorary distinguished research professor of National Taiwan University, Taipei Medical University and several other major universities in Taiwan.[38][39] He helps set up Integrative Evolutionary Galliform Genomics (iEGG) in National Chung Hsing University,[13] International Wound Repair and Regenerative Center (iWRR) in National Cheng Kung University,[1] and Integrative Stem Cell Center for China Medical University in Taiwan.[38] He has helped organize stem cells, biomimetics, and avian model systems meeting in Taiwan.[40]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 "Cheng-Ming Chuong, MD, PhD | Keck School of Medicine of USC" (in en-US). 31 July 2018. https://keck.usc.edu/faculty-search/cheng-ming-chuong/. 
  2. ↑ 2.0 2.1 2.2 2.3 2.4 "ORCID". https://orcid.org/0000-0001-9673-3994. 
  3. ↑ "Cheng-Ming Chuong | USC Profiles". https://profiles.sc-ctsi.org/cheng-ming.chuong. 
  4. ↑ 4.0 4.1 4.2 4.3 "Laboratory of Tissue Development and Regeneration". https://sites.usc.edu/cmchuong/. 
  5. ↑ 5.0 5.1 Chuong, Cheng-Ming (2013) (in en). Morphogenesis of Epithelial Appendages: Variations on Top of a Common Theme and Implications in Regeneration. Landes Bioscience. https://www.ncbi.nlm.nih.gov/books/NBK6047/. 
  6. ↑ Chuong, Cheng Ming; Homberger, Dominique G. (2003-08-15). "Development and Evolution of the Amniote Integument: Current Landscape and Future Horizon". Journal of Experimental Zoology Part B: Molecular and Developmental Evolution 298 (1): 1–11. doi:10.1002/jez.b.23. PMID 12949766. PMC 4386659. https://digitalcommons.lsu.edu/biosci_pubs/1746. 
  7. ↑ Chuong, Cheng-Ming; Richardson, Michael K. (2009). "Pattern formation today". The International Journal of Developmental Biology 53 (5–6): 653–658. doi:10.1387/ijdb.082594cc. ISSN 1696-3547. PMID 19557673. 
  8. ↑ Lai, Yung Chih; Chuong, Cheng-Ming (2016-12-23). "The "tao" of integuments". Science 354 (6319): 1533–1534. doi:10.1126/science.aal4572. ISSN 0036-8075. PMID 28008029. Bibcode: 2016Sci...354.1533L. 
  9. ↑ Jung, H. S.; Francis-West, P. H.; Widelitz, R. B.; Jiang, T. X.; Ting-Berreth, S.; Tickle, C.; Wolpert, L.; Chuong, C. M. (1998-04-01). "Local inhibitory action of BMPs and their relationships with activators in feather formation: implications for periodic patterning". Developmental Biology 196 (1): 11–23. doi:10.1006/dbio.1998.8850. ISSN 0012-1606. PMID 9527877. 
  10. ↑ 10.0 10.1 10.2 "Laboratory of Tissue Development and Regeneration". https://sites.usc.edu/cmchuong/. 
  11. ↑ Wu, Xiao-Shan; Yeh, Chao-Yuan; Harn, Hans I.-Chen; Jiang, Ting-Xing; Wu, Ping; Widelitz, Randall B.; Baker, Ruth E.; Chuong, Cheng-Ming (2019-05-28). "Self-assembly of biological networks via adaptive patterning revealed by avian intradermal muscle network formation". Proceedings of the National Academy of Sciences of the United States of America 116 (22): 10858–10867. doi:10.1073/pnas.1818506116. ISSN 1091-6490. PMID 31072931. 
  12. ↑ Jiang, T. X.; Jung, H. S.; Widelitz, R. B.; Chuong, C. M. (1999). "Self-organization of periodic patterns by dissociated feather mesenchymal cells and the regulation of size, number and spacing of primordia". Development 126 (22): 4997–5009. doi:10.1242/dev.126.22.4997. ISSN 0950-1991. PMID 10529418. 
  13. ↑ 13.0 13.1 Chang, Wei-Ling; Wu, Hao; Chiu, Yu-Kun; Wang, Shuo; Jiang, Ting-Xin; Luo, Zhong-Lai; Lin, Yen-Cheng; Li, Ang et al. (2019-11-27). "The Making of a Flight Feather: Bio-architectural Principles and Adaptation". Cell 179 (6): 1409–1423.e17. doi:10.1016/j.cell.2019.11.008. ISSN 1097-4172. PMID 31778655. 
  14. ↑ Liang, Ya-Chen; Wu, Ping; Lin, Gee-Way; Chen, Chih-Kuan; Yeh, Chao-Yuan; Tsai, Stephanie; Yan, Jie; Jiang, Ting-Xin et al. (2020-06-08). "Folding Keratin Gene Clusters during Skin Regional Specification". Developmental Cell 53 (5): 561–576.e9. doi:10.1016/j.devcel.2020.05.007. ISSN 1878-1551. PMID 32516596. 
  15. ↑ Plikus, Maksim V.; Mayer, Julie Ann; de la Cruz, Damon; Baker, Ruth E.; Maini, Philip K.; Maxson, Robert; Chuong, Cheng-Ming (2008-01-17). "Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration". Nature 451 (7176): 340–344. doi:10.1038/nature06457. ISSN 1476-4687. PMID 18202659. Bibcode: 2008Natur.451..340P. 
  16. ↑ Chuong, Cheng-Ming; Randall, Valerie A; Widelitz, Randall B.; Wu, Ping; Jiang, Ting-Xin (2012). "Physiological regeneration of skin appendages and implications for regenerative medicine". Physiology 27 (2): 61–72. doi:10.1152/physiol.00028.2011. ISSN 1548-9213. PMID 22505663. 
  17. ↑ Chen, Chih-Chiang; Murray, Philip J.; Jiang, Ting Xin; Plikus, Maksim V.; Chang, Yun-Ting; Lee, Oscar K.; Widelitz, Randall B.; Chuong, Cheng-Ming (2014-08-01). "Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4" (in en). Journal of Investigative Dermatology 134 (8): 2086–2096. doi:10.1038/jid.2014.139. ISSN 0022-202X. PMID 24618599. 
  18. ↑ Plikus, Maksim V.; Baker, Ruth E.; Chen, Chih-Chiang; Fare, Clyde; de la Cruz, Damon; Andl, Thomas; Maini, Philip K.; Millar, Sarah E. et al. (2011-04-29). "Self-organizing and stochastic behaviors during the regeneration of hair stem cells". Science 332 (6029): 586–589. doi:10.1126/science.1201647. ISSN 1095-9203. PMID 21527712. Bibcode: 2011Sci...332..586P. 
  19. ↑ Chen, Chih-Chiang; Wang, Lei; Plikus, Maksim V.; Jiang, Ting Xin; Murray, Philip J.; Ramos, Raul; Guerrero-Juarez, Christian F.; Hughes, Michael W. et al. (2015-04-09). "Organ-level quorum sensing directs regeneration in hair stem cell populations". Cell 161 (2): 277–290. doi:10.1016/j.cell.2015.02.016. ISSN 1097-4172. PMID 25860610. 
  20. ↑ Harn, Hans I.-Chen; Wang, Sheng-Pei; Lai, Yung-Chih; Van Handel, Ben; Liang, Ya-Chen; Tsai, Stephanie; Schiessl, Ina Maria; Sarkar, Arijita et al. (2021-05-10). "Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice". Nature Communications 12 (1): 2595. doi:10.1038/s41467-021-22822-9. ISSN 2041-1723. PMID 33972536. Bibcode: 2021NatCo..12.2595H. 
  21. ↑ Lei, Mingxing; Schumacher, Linus J.; Lai, Yung-Chih; Juan, Wen-Tau; Yeh, Chao-Yuan; Wu, Ping; Jiang, Ting-Xin; Baker, Ruth E. et al. (2017-08-22). "Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells". Proceedings of the National Academy of Sciences of the United States of America 114 (34): E7101–E7110. doi:10.1073/pnas.1700475114. ISSN 1091-6490. PMID 28798065. 
  22. ↑ Wu, Ping; Yan, Jie; Lai, Yung-Chih; Ng, Chen Siang; Li, Ang; Jiang, Xueyuan; Elsey, Ruth M.; Widelitz, Randall et al. (2018-02-01). "Multiple Regulatory Modules Are Required for Scale-to-Feather Conversion". Molecular Biology and Evolution 35 (2): 417–430. doi:10.1093/molbev/msx295. ISSN 1537-1719. PMID 29177513. 
  23. ↑ Wu, Ping; Wu, Xiaoshan; Jiang, Ting-Xin; Elsey, Ruth M.; Temple, Bradley L.; Divers, Stephen J.; Glenn, Travis C.; Yuan, Kuo et al. (2013-05-28). "Specialized stem cell niche enables repetitive renewal of alligator teeth". Proceedings of the National Academy of Sciences of the United States of America 110 (22): E2009–2018. doi:10.1073/pnas.1213202110. ISSN 1091-6490. PMID 23671090. Bibcode: 2013PNAS..110E2009W. 
  24. ↑ Xu, Xing; Zhou, Zhonghe; Dudley, Robert; Mackem, Susan; Chuong, Cheng-Ming; Erickson, Gregory M.; Varricchio, David J. (2014-12-12). "An integrative approach to understanding bird origins". Science 346 (6215). doi:10.1126/science.1253293. ISSN 1095-9203. PMID 25504729. 
  25. ↑ Pennisi, E.; Kaiser, J.; Service, R. F.; Gibbons, A.; Vogel, G.; Underwood, E.; Hand, E. (2014-12-19). "Runners-up". Science 346 (6216): 1444–1449. doi:10.1126/science.346.6216.1444. PMID 25525224. https://www.science.org/doi/10.1126/science.346.6216.1444. 
  26. ↑ Chuong, Cheng-Ming; Chen, Hai-Ming; Jiang, Ting-Xing; Chia, Jennifer (1991). "Adhesion Molecules in Skin Development: Morphogenesis of Feather and Haira" (in en). Annals of the New York Academy of Sciences 642 (1): 263–280. doi:10.1111/j.1749-6632.1991.tb24393.x. ISSN 1749-6632. PMID 1809086. Bibcode: 1991NYASA.642..263C. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.1991.tb24393.x. 
  27. ↑ 27.0 27.1 27.2 27.3 27.4 27.5 27.6 "Cheng Ming Chuong". https://www.phys.sinica.edu.tw/~tywufund/download/camp/2009/cv/cv_camp2009_ChengMingChuong.pdf. 
  28. ↑ Yu, Mingke; Wu, Ping; Widelitz, Randall B.; Chuong, Cheng-Ming (2002-11-21). "The morphogenesis of feathers" (in English). Nature 420 (6913): 308–312. doi:10.1038/nature01196. PMID 12442169. PMC 4386656. Bibcode: 2002Natur.420..308Y. https://go.gale.com/ps/i.do?p=AONE&sw=w&issn=00280836&v=2.1&it=r&id=GALE%7CA187569308&sid=googleScholar&linkaccess=abs. 
  29. ↑ "USC Associates Awards" (in en-US). https://www.provost.usc.edu/faculty-distinctions/university/usc-associates-awards/. 
  30. ↑ "Avian Model Systems 9". http://iegg.nchu.edu.tw/signup.html. 
  31. ↑ "USC Stem Cell researcher Cheng-Ming Chuong named fellow of national science association" (in en-US). 14 December 2014. https://stemcell.keck.usc.edu/usc-stem-cell-researcher-named-fellow-of-national-science-association/. 
  32. ↑ user (2015-09-19). "606. Cheng-Ming Chuong 鍾正明 / 2015/09" (in en-US). https://taiwaneseamericanhistory.org/blog/whoswho606/. 
  33. ↑ Plikus, Maksim V.; Widelitz, Randall B.; Maxson, Rob; Chuong, Cheng-Ming (2009). "Analyses of regenerative wave patterns in adult hair follicle populations reveal macro-environmental regulation of stem cell activity". The International Journal of Developmental Biology 53 (5–6): 857–868. doi:10.1387/ijdb.072564mp. ISSN 0214-6282. PMID 19378257. 
  34. ↑ "深入生技" (in zh). https://twbiogroup.org/. 
  35. ↑ Chuong, Cheng-Ming (in en). Tissue Patterning in living skin and organ ex. https://grantome.com/grant/NIH/R37-AR060306-11. 
  36. ↑ "Editors / Editorial Board" (in en-US). https://www.adf-online.de/journal-2/editors-editorial-board/. 
  37. ↑ "Editors | Scientific Reports" (in en). https://www.nature.com/srep/about/editors. 
  38. ↑ 38.0 38.1 "Integrative Stem Cell Center | Excellence" (in zh-Hant). http://www.cmuh.cmu.edu.tw/Department/Advanced_EN?depid=139. 
  39. ↑ "National Taiwan University_Spotlight130429". https://ntuweb.cloud.ntu.edu.tw/oldenglish/spotlight/2013/e130429_1.html. 
  40. ↑ "Avian Model Systems 9". http://iegg.nchu.edu.tw/signup.html. 



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