Biography:Gilean McVean

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Gil McVean

FRS FMedSci
Professor Gilean McVean FMedSci FRS.jpg
Gil McVean at the Royal Society admissions day in London in 2016
Born
Gilean Alistair Tristram McVean

(1973-02-25) 25 February 1973 (age 50)
NationalityBritish
Alma mater
Awards
  • Francis Crick Medal & Lecture (2010)[1]
  • Weldon Memorial Prize (2012)
  • Fellow of the Royal Society (2016)
  • Fellow of the Academy of Medical Sciences (2016)
Scientific career
Institutions
ThesisAdaptation and conflict : the differences between the sexes in mammalian genome evolution (1998)
Doctoral advisorLaurence Hurst[2][3][4]
Other academic advisors
WebsiteProfessor Gil McVean - University of Oxford

Gilean Alistair Tristram McVean (born 25 February 1973)[5] FRS FMedSci[6] is a professor of statistical genetics at the University of Oxford,[7] fellow of Linacre College, Oxford and co-founder and director of Genomics plc.[5][8] He also co-chaired the 1000 Genomes Project analysis group.[9][10]

Education

Gilean McVean speaking at the 2010 GEM meeting at the Wellcome Trust Sanger Institute, Hinxton

From 1991-94, he completed a Bachelor of Arts degree in Biological Sciences at the University of Oxford.[11] He completed his PhD in the Department of Genetics at the University of Cambridge supervised by Laurence Hurst[12][13] in 1998.[3][14]

Career and research

McVean completed postdoctoral research at the University of Edinburgh from 1997 to 2000, supervised by Brian and Deborah Charlesworth.[15][14]

From 2000-04, he was a Royal Society University Research Fellow in the Department of Statistics at Oxford, where he has also been a University lecturer in Mathematical Genetics since 2004. He was reappointed in 2009 until retirement age.[16] In October 2006, he was appointed professor of statistical genetics at the University of Oxford.[17]

McVean's research[18] focuses on population genetics, statistics[19] and evolutionary biology including the International HapMap Project,[20][21] recombination rates in the human genome[22] and the 1000 Genomes Project.[23][24]

McVean developed a statistical method to look at recombination rate which helped to identify PRDM9 as a hotspot positioning gene.[25] In 2014, with Peter Donnelly, McVean co-founded Genomics plc, a genomics analysis company, as a corporate spin-off of the University of Oxford.[5] In 2017, he was a founding director of the Big Data Institute at the University of Oxford.[26]

Honours and awards

In 2006 McVean was awarded a Philip Leverhulme Prize.[27][28]

In 2010, McVean was awarded the Francis Crick Medal and delivered that year's lecture entitled "Our genomes, our history".[29]

In 2012, he was awarded the Weldon Memorial Prize.[30]

In 2013, he presented a talk TEDxWarwick entitled A Thousand Genomes a Thousand Stories.[31]

In May 2014, McVean was elected as a member of the European Molecular Biology Organisation.[32]

McVean was elected Fellow of the Royal Society (FRS) in 2016[6] and a Fellow of the Academy of Medical Sciences (FMedSci).[33][34]

References

  1. ↑ "Francis Crick Medal and Lecture 2010 - Our genomes, our history". https://royalsociety.org/science-events-and-lectures/2010/genomes-history/. 
  2. ↑ Hurst, L.; McVean, G. (1996). "A difficult phase for introns-early. Molecular evolution". Current Biology 6 (5): 533–36. doi:10.1016/S0960-9822(02)00535-3. PMID 8805261. 
  3. ↑ 3.0 3.1 McVean, Gilean Alistair Tristram (1998). Adaptation and conflict: the differences between the sexes in mammalian genome evolution (PhD thesis). University of Cambridge. OCLC 894602716.
  4. ↑ "Students and post-docs past and present in the Hurst laboratory". University of Bath. Archived on 15 May 2015. Error: If you specify |archivedate=, you must also specify |archiveurl=. http://people.bath.ac.uk/bssldh/LaurenceDHurst/Lab_members.html. 
  5. ↑ 5.0 5.1 5.2 Anon (2016). "Gilean MCVEAN Profile". London: Companies House. Archived from the original on 12 August 2016. https://web.archive.org/web/20160812100701/https://beta.companieshouse.gov.uk/officers/Vk-hS4VIl5UrT2x7UrxKzWVL6Mo/appointments. 
  6. ↑ 6.0 6.1 Anon (2016). "Gilean McVean". London: Royal Society. Archived from the original on 29 April 2016. https://web.archive.org/web/20160429121403/https://royalsociety.org/people/gilean-mcvean-12885. 
  7. ↑ McVean Group at the University of Oxford
  8. ↑ "Prof. Gil McVean - GENOMICS plc". http://www.genomicsplc.com/team/prof-gil-mcvean. 
  9. ↑ "Oct 10: 1000 Genomes project - Wellcome Trust Centre for Human Genetics". http://www.well.ox.ac.uk/oct-10-1000-genomes-project. 
  10. ↑ Gilean McVean publications from Europe PubMed Central
  11. ↑ Gil McVean's Entry at ORCID
  12. ↑ McVean, G.T.; Hurst, L.D. (1997). "Evidence for a selectively favourable reduction in the mutation rate of the X chromosome". Nature 386 (6623): 388–92. doi:10.1038/386388a0. PMID 9121553. Bibcode: 1997Natur.386..388M. 
  13. ↑ Hurst, L.D.; McVean, G.T. (1996). "...And scandalous symbionts". Nature 381 (6584): 650–51. doi:10.1038/381650a0. PMID 8649507. Bibcode: 1996Natur.381..650H. 
  14. ↑ 14.0 14.1 "Gilean McVean profile". http://www.stats.ox.ac.uk/people/academic_staff/gilean_mcvean. 
  15. ↑ Charlesworth, D.; Charlesworth, B.; McVean, G. (2001). "Genome sequences and evolutionary biology, a two-way interaction". Trends in Ecology & Evolution 16 (5): 235–42. doi:10.1016/S0169-5347(01)02126-7. PMID 11301152. 
  16. ↑ "Oxford University Gazette - Reappointments". 14 May 2009. http://www.ox.ac.uk/gazette/2008-9/weekly/140509/exam.htm. 
  17. ↑ "Oxford University Gazette". http://www.ox.ac.uk/gazette/2006-7/supps/1_4784.htm. 
  18. ↑ Gilean McVean profile, Google Scholar; accessed 30 December 2017.
  19. ↑ Reshef, D. N.; Reshef, Y. A.; Finucane, H. K.; Grossman, S. R.; McVean, G.; Turnbaugh, P. J.; Lander, E. S.; Mitzenmacher, M. et al. (2011). "Detecting Novel Associations in Large Data Sets". Science 334 (6062): 1518–1524. doi:10.1126/science.1205438. PMID 22174245. Bibcode: 2011Sci...334.1518R. 
  20. ↑ Frazer, K. A.; Frazer, D. G.; Ballinger, D. R.; Cox, D. A.; Hinds, L. L.; Stuve, R. A.; Gibbs, J. W.; Belmont, A. et al. (2007). "A second generation human haplotype map of over 3.1 million SNPs". Nature 449 (7164): 851–61. doi:10.1038/nature06258. PMID 17943122. Bibcode: 2007Natur.449..851F. 
  21. ↑ Sabeti, Pardis C.; Varilly, Patrick; Fry, Ben; Lohmueller, Jason; Hostetter, Elizabeth; Cotsapas, Chris; Xie, Xiaohui; Byrne, Elizabeth H. et al. (2007). "Genome-wide detection and characterization of positive selection in human populations". Nature 449 (7164): 913–918. doi:10.1038/nature06250. PMID 17943131. Bibcode: 2007Natur.449..913S. 
  22. ↑ McVean, G. A. T.; Myers, S.; Hunt, S.; Deloukas, P.; Bentley, D.; Donnelly, P. (2004). "The Fine-Scale Structure of Recombination Rate Variation in the Human Genome". Science 304 (5670): 581–584. doi:10.1126/science.1092500. PMID 15105499. Bibcode: 2004Sci...304..581M. 
  23. ↑ Danecek, P.; Auton, A.; Abecasis, G.; Albers, C. A.; Banks, E.; Depristo, M. A.; Handsaker, R.; Lunter, G. et al. (2011). "The Variant Call Format and VCFtools". Bioinformatics 27 (15): 2156–58. doi:10.1093/bioinformatics/btr330. PMID 21653522. 
  24. ↑ Hernandez, R. D.; Kelley, J. L.; Elyashiv, E.; Melton, S. C.; Auton, A.; McVean, G.; 1000 Genomes Project; Sella, G. et al. (2011). "Classic Selective Sweeps Were Rare in Recent Human Evolution". Science 331 (6019): 920–24. doi:10.1126/science.1198878. PMID 21330547. Bibcode: 2011Sci...331..920H. 
  25. ↑ "Gilean McVean". https://royalsociety.org/people/gilean-mcvean-12885/. 
  26. ↑ "Professor Cecilia Lindgren appointed Director of the Big Data Institute — Oxford Big Data Institute". https://www.bdi.ox.ac.uk/news/professor-cecilia-lindgren-appointed-director-of-the-big-data-institute. 
  27. ↑ "AWARDS MADE IN 2006". The Leverhulme Trust. 2006. https://www.leverhulme.ac.uk/sites/default/files/imported_pdfs/2006.pdf. 
  28. ↑ "Philip Leverhulme Prizes 2006". The Leverhulme Trust. 2006. https://www.leverhulme.ac.uk/sites/default/files/imported_pdfs/philip_prize_2006.pdf. 
  29. ↑ The Royal Society (10 December 2013), Our genomes, our history, https://www.youtube.com/watch?v=_noqZ2jm_74, retrieved 30 December 2017 
  30. ↑ "Professor Gil McVean awarded the Weldon Memorial Prize 2012 - Wellcome Trust Centre for Human Genetics". http://www.well.ox.ac.uk/professor-gil-mcvean-awarded-the-weldon-memorial-prize-2012. 
  31. ↑ TEDx Talks (2013-03-29), A Thousand Genomes a Thousand Stories: Gilean McVean at TEDxWarwick 2013, https://www.youtube.com/watch?v=LBn__zsd7-4, retrieved 30 December 2017 
  32. ↑ "EMBO enlarges its membership for 50th anniversary". http://www.embo.org/news/press-releases/2014/embo-enlarges-its-membership-for-50th-anniversary. 
  33. ↑ "New Fellows: Academy of Medical Sciences". http://www.acmedsci.ac.uk/fellows/fellowship-news/new-fellows. 
  34. ↑ "Professor Gil McVean elected a Fellow of the Royal Society - GENOMICS plc". http://www.genomicsplc.com/professor-gil-mcvean-elected-a-fellow-of-the-royal-society/. 




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