Biography:Jason Sheltzer

From HandWiki

Jason Sheltzer is a cancer biologist at the Yale University School of Medicine.[1]

Education

Sheltzer received a BA in molecular biology from Princeton University and a PhD in biology from the Massachusetts Institute of Technology.[2][3] At MIT, Sheltzer performed his PhD research with Angelika Amon on the consequences of aneuploidy.[4] Sheltzer then established his own research group as an independent fellow at Cold Spring Harbor Laboratory.[5][3] In 2021 Sheltzer was recruited to move his lab to Yale University.[1]

Career and research

Sheltzer uses CRISPR/Cas9 technology to study aneuploidy and cancer genomics.[6][7] Through the use of chromosome engineering, he has constructed cancer cells with different degrees of aneuploidy, and he has found how aneuploidy affects tumor development and metastasis.[8][9][10] In 2019, he discovered a set of copy number alteration biomarkers that can be used to predict cancer patient outcomes.[5][11][12] His research has questioned whether anti-cancer drugs could be acting through alternate mechanisms.[13][14][15] He is a co-founder of Meliora Therapeutics.[16]

Sheltzer also studies gender disparities in biology research. He discovered that some faculty members, like Nobel Prize winners, tended to hire very few female students in their labs, which could contribute to the gender gap in STEM.[17][18][19]

Awards and honors

References

  1. ↑ 1.0 1.1 Smith, Cecelia. "Geneticist and Diversity Champion Jason Sheltzer Brings Award-Winning Research Lab to Yale Surgery" (in en). https://medicine.yale.edu/news-article/geneticist-jason-sheltzer-brings-award-winning-lab-to-yale/. 
  2. ↑ Austin, Jim (2014-07-08). "A Young Tag Team Detects a Major Pipeline Leak" (in en). https://www.science.org/content/article/young-tag-team-detects-major-pipeline-leak. 
  3. ↑ 3.0 3.1 "AACR-Bayer Innovation and Discovery Grants | American Association for Cancer Research" (in en). https://www.aacr.org/professionals/research-funding/independent-investigator-grant-recipients/aacr-bayer-innovation-and-discovery-grants/. 
  4. ↑ "McKinley and Sheltzer to Receive 2016 Bernfield and Gilula Awards" (in en-US). 2016-10-06. https://www.ascb.org/member-news/mckinley-sheltzer-receive-2016-bernfield-gilula-awards/. 
  5. ↑ 5.0 5.1 Ricks, Delthia (2018-12-25). "Researcher aims to take uncertainty out of cancer diagnosis" (in en). https://www.newsday.com/news/health/cancer-gene-cold-spring-harbor-1.24781725. 
  6. ↑ "Fox 5 (New York): Modifying Cancer Cell Genomes [The Big Idea"]. 2018-09-20. https://www.youtube.com/watch?v=xypH32pDcV8. 
  7. ↑ Kaiser, Jocelyn (2019-09-11). "Some cancer drugs miss their target. CRISPR could improve their aim" (in en). https://www.science.org/content/article/some-cancer-drugs-miss-their-target-crispr-could-improve-their-aim. 
  8. ↑ Seton-Rogers, Sarah (March 2017). "Fitness penalties of aneuploidy" (in en). Nature Reviews Cancer 17 (3): 142–143. doi:10.1038/nrc.2017.9. ISSN 1474-1768. PMID 28184042. https://www.nature.com/articles/nrc.2017.9. 
  9. ↑ Seton-Rogers, Sarah (2020-03-31). "Weighing up effects of extra chromosomes" (in en). Nature Reviews Cancer 20 (5): 259. doi:10.1038/s41568-020-0257-y. ISSN 1474-175X. PMID 32235903. 
  10. ↑ Johnson, Carolyn Y. (2023-07-06). "Gene editing helped crack a 100-year-old mystery about cancer" (in en-US). Washington Post. ISSN 0190-8286. https://www.washingtonpost.com/science/2023/07/06/cancer-cells-extra-chromosomes/. 
  11. ↑ Thomas, Uduak Grace (2018-12-18). "Cancer Genetic Studies Explore Prognostic Value of Copy Number Alterations, Other Biomarkers" (in en-us). https://www.genomeweb.com/cancer/cancer-genetic-studies-explore-prognostic-value-copy-number-alterations-other-biomarkers. 
  12. ↑ Dunaief, Daniel. "CSHL's Jason Sheltzer and Google's Joan Smith team up in cancer study | TBR News Media" (in en-US). https://tbrnewsmedia.com/cshls-jason-sheltzer-and-googles-joan-smith-team-up-in-cancer-study/. 
  13. ↑ Zimmer, Carl (2019-09-11). "Why Aren't Cancer Drugs Better? The Targets Might Be Wrong" (in en-US). The New York Times. ISSN 0362-4331. https://www.nytimes.com/2019/09/11/health/cancer-drugs-proteins.html. 
  14. ↑ Belluz, Julia (2019-09-16). "Most cancer drugs fail in testing. This might be a big reason why." (in en). https://www.vox.com/2019/9/16/20864066/cancer-studies-fail. 
  15. ↑ Preidt, Robert (2019-09-11). "Cancer Drugs Sometimes Work in Unexpected Ways: Study". https://www.usnews.com/news/health-news/articles/2019-09-11/cancer-drugs-sometimes-work-in-unexpected-ways-study. 
  16. ↑ Gormley, Brian. "Biotech Meliora Therapeutics Gets $11 Million Seed Financing for Cancer Treatments" (in en-US). https://www.wsj.com/articles/biotech-meliora-therapeutics-gets-11-million-seed-financing-for-cancer-treatments-11664445603. 
  17. ↑ McGregor, Jenna (2014-07-17). "Study: Top labs run by men tend to hire fewer women". The Washington Post. https://www.washingtonpost.com/news/on-leadership/wp/2014/07/17/study-top-labs-run-by-men-tend-to-hire-fewer-women/. 
  18. ↑ Dockterman, Eliana (2014-07-09). "Study: Male Scientists Employ Fewer Women in Labs" (in en). Time. https://time.com/2969814/women-male-scientists/. Retrieved 2020-06-06. 
  19. ↑ Hu, Jane C. (2014-06-30). "Male Professors Rarely Train Female Scientists" (in en). https://slate.com/human-interest/2014/06/women-in-science-a-new-study-on-how-male-professors-discriminate-against-women-in-scientific-labs.html. 
  20. ↑ "Jason Sheltzer, 28" (in en). https://www.forbes.com/pictures/ggik45ekh/jason-sheltzer-28/. 
  21. ↑ "McKinley and Sheltzer to Receive 2016 Bernfield and Gilula Awards" (in en-US). 2016-11-07. https://www.ascb.org/member-news/mckinley-sheltzer-receive-2016-bernfield-gilula-awards-november-december-2016-newsletter/. 
  22. ↑ "President Donald J. Trump Announces Recipients of the Presidential Early Career Award for Scientists and Engineers" (in en-US). whitehouse.gov. https://trumpwhitehouse.archives.gov/briefings-statements/president-donald-j-trump-announces-recipients-presidential-early-career-award-scientists-engineers/. 



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