Biography:Konstantinos Drosatos
Konstantinos Drosatos | |
|---|---|
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| Born | Athens, Greece |
| Nationality | Greek |
| Citizenship | Greek & USA |
| Education |
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| Alma mater | Aristotle University of Thessaloniki |
| Scientific career | |
| Institutions |
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| Thesis | Gene regulation and functions of Apolipoprotein E (2007) |
| Website | www |
Konstantinos Drosatos (Greek: Κωνσταντίνος Δροσάτος), born in Athens, Greece, is a Greek-American molecular biologist, who is the Ohio Eminent Scholar and Professor of Pharmacology and Systems Physiology at the University of Cincinnati College of Medicine in Cincinnati, Ohio, U.S. His parents were Georgios Drosatos and Sofia Drosatou; his family originates in Partheni, Euboea, Greece.[1]
Education and career
Drosatos received his B.Sc. from the department of biology at the Aristotle University of Thessaloniki, Greece in 2000. In 2000, he continued with graduate studies at the Molecular Biology-Biomedicine graduate program of the department of biology and the medical school of the University of Crete. He received his M.Sc. in 2002 and his Ph.D. in molecular biology-biomedicine in 2007. During his graduate studies (2002–2007) he was a visiting research scholar in the laboratory of Vassilis I. Zannis[2] at Boston University Medical School. Following his graduation with a PhD in molecular biology-biomedicine in 2007, he joined the laboratory of Ira J. Goldberg at Columbia University, where he pursued post-doctoral training until 2012,[3] when he was promoted to associate research scientist in the department of medicine at Columbia University. In 2014 he joined the faculty of the Lewis Katz School of Medicine at Temple University as an assistant professor in pharmacology and in 2020, he was promoted to associate professor with tenure in cardiovascular sciences (primary affiliation). In 2022, he was recruited at the University of Cincinnati College of Medicine, which he joined as the Ohio Eminent Scholar and Professor of Pharmacology and Systems Physiology [4]
Research interests
The research in his laboratory focuses on cardiovascular and systemic metabolism and particularly on signaling mechanisms that link cardiac stress in diabetes, sepsis and ischemia with altered myocardial fatty acid metabolism. His published work focuses on the transcriptional regulation of proteins that underlie lipoprotein metabolism, cardiac and systemic fatty acid metabolism, and mitochondrial function. His work has identified the role of Krüppel-like factor 5 (KLF5) in the regulation of cardiac fatty acid metabolism in diabetes[5][6] and ischemic heart failure,[7] as well as how cardiac lipotoxicity leads to cardiac dysfunction,[8][9] and the importance of cardiac fatty acid oxidation and mitochondrial integrity for the treatment of cardiac dysfunction in sepsis.[10][11][12]
Distinctions and awards
- 2014 Outstanding Early Career Award recipient, American Heart Association, BCVS Council[13]
- 2016 Honorary Citizen, Eastern Mani Municipality, Greece
- 2016 Visiting Professor, UCLA Center for Systems Biomedicine
- 2017 Early Research Investigator Award, Lewis Katz School of Medicine at Temple University
- 2017 Elected Fellow (FAHA), American Heart Association
- 2019 Elected Full Member, Sigma Xi, The Scientific Research Honor Society[14]
Leadership positions
- 2006–2010 – founding president of the board of directors, Hellenic Bioscientific Association of the USA[15]
- 2012–2014 – president of the executive board, World Hellenic Biomedical Association[16]
- 2019–present – vice-president of the executive council, ARISTEiA-Institute for the Advancement of Research & Education in Arts, Sciences & Technology[17]
- 2020-2021 - Chair-elect of the Mid-career Committee, International Society for Heart Research-North American Section
References
- ↑ "Partheni, Euboea, Greece". https://partheni.weebly.com/.
- ↑ "Laboratory of Vassilis I. Zannis". http://people.bu.edu/vzannis/people.htm.
- ↑ "New and Competitively Renewed Peer-Reviewed Awards Received in 2012 (Columbia University, Department of Medicine)". http://columbiamedicine.org/research/grants2012.shtml.
- ↑ "University of Cincinnati College of Medicine - Profile of Konstantinos Drosatos". https://researchdirectory.uc.edu/p/drosatks.
- ↑ Drosatos, Konstantinos (16 November 2015). "Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function". Circulation Research 118 (2): 241–253. doi:10.1161/CIRCRESAHA.115.306383. PMID 26574507.
- ↑ Kyriazis, Ioannis D.; Hoffman, Matthew; Gaignebet, Lea; Lucchese, Anna Maria; Markopoulou, Eftychia; Palioura, Dimitra; Wang, Chao; Bannister, Thomas D. et al. (2021). "KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy". Circulation Research 128 (3): 335–357. doi:10.1161/CIRCRESAHA.120.316738. PMID 33539225.
- ↑ Hoffman, Matthew; Palioura, Dimitra; Kyriazis, Ioannis D.; Cimini, Maria; Badolia, Rachit; Rajan, Sudarsan; Gao, Erhe; Nikolaidis, Nikolas et al. (March 16, 2021). "Cardiomyocyte Krüppel-Like Factor 5 Promotes De Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy". Circulation 143 (11): 1139–1156. doi:10.1161/CIRCULATIONAHA.120.047420. ISSN 0009-7322. PMID 33430631.
- ↑ Drosatos, Konstantinos; Bharadwaj, Kalyani G.; Lymperopoulos, Anastasios; Ikeda, Shota; Khan, Raffay; Hu, Yunying; Agarwal, Rajiv; Yu, Shuiqing et al. (2011). "Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation". American Journal of Physiology. Endocrinology and Metabolism 300 (3): E489-99. doi:10.1152/ajpendo.00569.2010. PMID 21139071.
- ↑ Bosma, Madeleen; Dapito, Dianne H.; Drosatos-Tampakaki, Zoi; Huiping-Son, Ni; Huang, Li-Shin; Kersten, Sander; Drosatos, Konstantinos; Goldberg, Ira J. (December 2014). "Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1841 (12): 1648–1655. doi:10.1016/j.bbalip.2014.09.012. PMID 25251292.
- ↑ Drosatos, Konstantinos; Drosatos-Tampakaki, Zoi; Khan, Raffay; Homma, Shunichi; Schulze, P. Christian; Zannis, Vassilis I.; Goldberg, Ira J. (October 21, 2011). "Inhibition of c-Jun-N-terminal kinase increases cardiac peroxisome proliferator-activated receptor alpha expression and fatty acid oxidation and prevents lipopolysaccharide-induced heart dysfunction". Journal of Biological Chemistry 286 (42): 36331–36339. doi:10.1074/jbc.M111.272146. PMID 21873422.
- ↑ Drosatos, Konstantinos; Khan, Raffay S.; Trent, Chad M.; Jiang, Hongfeng; Son, Ni-Huiping; Blaner, William S.; Homma, Shunichi; Schulze, P. Christian et al. (9 April 2013). "Peroxisome proliferator-activated receptor-γ activation prevents sepsis-related cardiac dysfunction and mortality in mice". Circulation: Heart Failure 6 (3): 550–562. doi:10.1161/CIRCHEARTFAILURE.112.000177. PMID 23572494.
- ↑ Kokkinaki, Dimitra; Hoffman, Matthew; Kalliora, Charikleia; Kyriazis, Ioannis D.; Maning, Jennifer; Lucchese, Anna Maria; Shanmughapriya, Santhanam; Tomar, Dhanendra et al. (February 1, 2019). "Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy". Journal of Molecular and Cellular Cardiology 127: 232–245. doi:10.1016/j.yjmcc.2018.12.016. PMID 30611795. PMC 6359996. https://www.jmcc-online.com/article/S0022-2828(18)31139-8/fulltext.
- ↑ "Credentials, Lewis Katz School of Medicine at Temple University". https://medicine.temple.edu/konstantinos-drosatos.
- ↑ "Members Directory, Sigma Xi, The Scientific Research Honor society". https://www.sigmaxi.org/members/member-directory?fn=Konstantinos&ln=Drosatos&disc=0&match=False.
- ↑ "Hellenic Bioscientific Association of the USA - Current and past leadership". http://www.hbausa.org/about-us/board-of-directors/.
- ↑ "World Hellenic Biomedical Association - Past Presidents". http://www.whba1990.org/past-presidents.html.
- ↑ "ARISTEiA - Executive Council Members". https://www.aristeia.us/drosatos.html.
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