Biography:Mark Lathrop

Mark Lathrop
Born	1950
Citizenship	Canada
Alma mater	University of Alberta University of Washington (Ph.D)
Known for	genomic research
Awards	Ordre national du Mérite Legion of Honour
Scientific career
Fields	biostatistics, genetics
Institutions	University of Oxford Centre d’Étude du Polymorphisme Humain Centre National de Génotypage McGill University
Website	https://genomic.medicine.mcgill.ca/investigator/mark-lathrop

Mark Lathrop (born 1950) is a Canadian genomic researcher and Biostatistician. He headed the Center for the Study of Human Polymorphisms in France. As of 2011, he is the Scientific Director of the McGill University and Génome Québec Innovation Centre in 2011. His research is focused on "the application of genomics and statistical/mathematical methods to understand the molecular basis of human disease."

Education

Lathrop earned his undergraduated and master's degrees at the University of Alberta. He then studied theoretical statistics and genetics at the University of Washington, where he earned his PhD in biomathematics.

Career

After completing his doctorate, Lathrop moved to France. There he founded the Center for the Study of Human Polymorphism. In the 1980s and 1990s, the Centre was at the forefront of research on the human genome.

Lathrop, recruited by Sir John Bell, moved to Oxford, England in 1993, where he became co-founder and director of Wellcome Trust Centre for Human Genetics (WHG) at the University of Oxford.

In 1998, he returned to France where he founded the Centre National de Génotypage (CNG), France's national centre for the study human genetics.

In 2011, Lathrop returned to Canada to McGill University, where he was named the Scientific Director of the McGill University Genome Centre, and a Professor in the Department of Human Genetics. His current research focuses on "using genetic approaches to identify DNA variants that predispose people to common diseases", especially, "lung cancer, asthma and cardiovascular disease."

Honors

Lathrop has been honored with the French National Award of Merit and French Legion of Honour.

Personal

Lathrop has dual citizenship - in Canada and France.

Bibliography

• Hung, Rayjean J et al. (April 2008). "A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25". Nature 452 (7187): 633–7. doi:10.1038/nature06885. PMID 18385738. Bibcode: 2008Natur.452..633H. https://hal-cea.archives-ouvertes.fr/cea-00944415/file/Hung1.pdf. 
• Moffatt, Miriam F et al. (July 2007). "Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma". Nature 448 (7152): 470–3. doi:10.1038/nature06014. PMID 17611496. Bibcode: 2007Natur.448..470M. https://deepblue.lib.umich.edu/bitstream/2027.42/62682/1/nature06014.pdf. 
• Bouzigon, Emmanuelle; Corda Eve; Aschard Hugues; Dizier Marie-Hélène; Boland Anne; Bousquet Jean; Chateigner Nicolas; Gormand Frédéric et al. (November 2008). "Effect of 17q21 variants and smoking exposure in early-onset asthma". N. Engl. J. Med. 359 (19): 1985–94. doi:10.1056/NEJMoa0806604. PMID 18923164. 
• Spanagel, Rainer; Pendyala Gurudutt; Abarca Carolina; Zghoul Tarek; Sanchis-Segura Carles; Magnone Maria Chiara; Lascorz Jesús; Depner Martin et al. (January 2005). "The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption". Nat. Med. 11 (1): 35–42. doi:10.1038/nm1163. ISSN 1078-8956. PMID 15608650. http://doc.rero.ch/record/4324/files/1_albrecht_cgp.pdf. 
• Kathiresan, S et al. (December 2008). "Common variants at 30 loci contribute to polygenic dyslipidemia". Nat. Genet. 41 (1): 56–65. doi:10.1038/ng.291. PMID 19060906. 
• McKay, James D et al. (December 2008). "Lung cancer susceptibility locus at 5p15.33". Nat. Genet. 40 (12): 1404–6. doi:10.1038/ng.254. PMID 18978790. 
• Barrett, Jeffrey C et al. (August 2008). "Genome-wide association defines more than thirty distinct susceptibility loci for Crohn's disease". Nat. Genet. 40 (8): 955–62. doi:10.1038/ng.175. PMID 18587394. 
• Saar Kathrin (May 2008). "SNP and haplotype mapping for genetic analysis in the rat". Nat. Genet. 40 (5): 560–6. doi:10.1038/ng.124. PMID 18443594. 
• Willer, Cristen J; Sanna, S; Jackson, AU; Scuteri, A; Bonnycastle, LL; Clarke, R; Heath, SC; Timpson, NJ et al. (February 2008). "Newly identified loci that influence lipid concentrations and risk of coronary artery disease". Nat. Genet. 40 (2): 161–9. doi:10.1038/ng.76. PMID 18193043. 
• Wellcome Trust Case Control Consortium; Australo-Anglo-American Spondylitis Consortium (TASC); Burton, PR; Clayton, DG; Cardon, LR; Craddock, N; Deloukas, P; Duncanson, A et al. (November 2007). "Association scan of 14,500 nsSNPs in four common diseases identifies variants involved in autoimmunity". Nat. Genet. 39 (11): 1329–37. doi:10.1038/ng.2007.17. PMID 17952073. 
• Dixon, Anna L; Liang Liming; Moffatt Miriam F; Chen Wei; Heath Simon; Wong Kenny C C; Taylor Jenny; Burnett Edward et al. (October 2007). "A genome-wide association study of global gene expression". Nat. Genet. 39 (10): 1202–7. doi:10.1038/ng2109. PMID 17873877. 
• Menzel, Stephan; Garner Chad; Gut Ivo; Matsuda Fumihiko; Yamaguchi Masao; Heath Simon; Foglio Mario; Zelenika Diana et al. (October 2007). "A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15". Nat. Genet. 39 (10): 1197–9. doi:10.1038/ng2108. PMID 17767159. 
• Fischer, Judith; Lefèvre Caroline; Morava Eva; Mussini Jean-Marie; Laforêt Pascal; Negre-Salvayre Anne; Lathrop Mark; Salvayre Robert (January 2007). "The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy". Nat. Genet. 39 (1): 28–30. doi:10.1038/ng1951. ISSN 1061-4036. PMID 17187067. 
• Delmaghani, Sedigheh; del Castillo Francisco J; Michel Vincent; Leibovici Michel; Aghaie Asadollah; Ron Uri; Van Laer Lut; Ben-Tal Nir et al. (July 2006). "Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy". Nat. Genet. 38 (7): 770–8. doi:10.1038/ng1829. ISSN 1061-4036. PMID 16804542. 
• Sakuntabhai, Anavaj; Turbpaiboon, C; Casadémont, I; Chuansumrit, A; Lowhnoo, T; Kajaste-Rudnitski, A; Kalayanarooj, SM; Tangnararatchakit, K et al. (May 2005). "A variant in the CD209 promoter is associated with severity of dengue disease". Nat. Genet. 37 (5): 507–13. doi:10.1038/ng1550. ISSN 1061-4036. PMID 15838506. 
• Auwerx, Johan; Avner, P; Baldock, R; Ballabio, A; Balling, R; Barbacid, M; Berns, A; Bradley, A et al. (September 2004). "The European dimension for the mouse genome mutagenesis program". Nat. Genet. 36 (9): 925–7. doi:10.1038/ng0904-925. ISSN 1061-4036. PMID 15340424. 
• Gut, Ivo G; Lathrop G Mark (August 2004). "Duplicating SNPs". Nat. Genet. 36 (8): 789–90. doi:10.1038/ng0804-789. ISSN 1061-4036. PMID 15284844. 
• Allen, Maxine; Heinzmann Andrea; Noguchi Emiko; Abecasis Gonçalo; Broxholme John; Ponting Chris P; Bhattacharyya Sumit; Tinsley Jon et al. (November 2003). "Positional cloning of a novel gene influencing asthma from chromosome 2q14". Nat. Genet. 35 (3): 258–63. doi:10.1038/ng1256. ISSN 1061-4036. PMID 14566338. 
• Caulfield, Mark; Munroe Patricia; Pembroke Janine; Samani Nilesh; Dominiczak Anna; Brown Morris; Benjamin Nigel; Webster John et al. (June 2003). "Genome-wide mapping of human loci for essential hypertension". Lancet 361 (9375): 2118–23. doi:10.1016/S0140-6736(03)13722-1. PMID 12826435.