Biography:Nicolas Le Novère

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Nicolas Le Novère
VIB-ABLS-2016-cropped.jpg
Born (1969-03-12) 12 March 1969 (age 54)
Alma mater
  • École Normale Supérieure
  • Pierre and Marie Curie University
  • University of Paris-Sud
Known forBioModels Database, SBGN, SBML, MIRIAM
Scientific career
Fields
Institutions
Academic advisors
  • Jean-Pierre Changeux
  • Dennis Bray

Nicolas Le Novère is a British and France biologist. His research focus on modeling signaling pathways and developing tools to share mathematical models.

Education

Le Novère obtained his Baccalauréat at the Prytanée National Militaire. He received a MSc (1993) in Biology and Biochemistry from the École Normale Supérieure, a BSc in Cellular Biology and Physiology (1991), and a PhD in Molecular and Cellular Pharmacology (1998) from the Pierre and Marie Curie University.[1] From 1999 to 2001, he was a Postdoctoral Fellow at the University of Cambridge (UK).

Research

The first part of Le Novère's career, in the laboratory of Jean-Pierre Changeux at the Pasteur Institute, was focused on studying Nicotinic acetylcholine receptors in the brain. He reconstructed their phylogeny,[2] predicted[3] and modeled their structure.[4] He also investigated the role of the alpha6 subunit in the dopaminergic neurons of the mesencephalon.[5][6]

During his post-doctoral fellowship in the group of Dennis Bray at the University of Cambridge, he modeled the molecular networks underlying bacterial chemotaxis.[7][8] Le Novère then became involved in the development standards to share mathematical models such as SBML,[9] of which he would later become editor.

In 2003, Le Novère built a research group at the European Bioinformatics Institute (EMBL-EBI). The group studied the signaling pathways underlying synaptic plasticity, in particular the allosteric calcium sensors.[10][11][12] In parallel, his group coordinated the development of a consistent set of standards in systems biology, including the graphical notation SBGN,[13] the guidelines MIRIAM[14] and MIASE,[15] the languages SED-ML[16] and PharmML, and ontologies[17] such as the Systems Biology Ontology. He also created BioModels Database[18] and the Identifiers.org[19] URIs.

Le Novère moved his group to the Babraham Institute from 2012 to 2018.

He was associate editor of the journals BMC Systems Biology and NPJ Systems Biology and Applications until September 2018. He has been section head for the section Systems and Network Biology of the Faculty of 1000 from 2017 to 2018.

Senior member of the International Society for Computational Biology, he served on its Board of Directors from 2017 to 2018.

Conviction

In September 2018, Le Novère was sentenced for 8 month (suspended for 2 years) when he admitted downloading indecent images of a child and possession of an extreme pornographic image. [20][21][22] Subsequently, he was dismissed from the Babraham Institute where he was working.

References

  1. ↑ "Nicolas Le Novere CV". http://lenoverelab.org/perso/lenov/cv.html. Retrieved 25 July 2015. 
  2. ↑ "Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells". Journal of Molecular Evolution 40 (2): 155–172. 1995. doi:10.1007/BF00167110. PMID 7699721. 
  3. ↑ "Improved secondary structure predictions for a nicotinic receptor subunit. Incorporation of solvent accessibility and experimental data into a 2D representation". Biophysical Journal 76 (5): 2329–2345. 1999. doi:10.1016/S0006-3495(99)77390-X. PMID 10233052. 
  4. ↑ "Models of the extracellular domain of the nicotinic receptors and of agonist and Ca++ binding sites". Proceedings of the National Academy of Sciences USA 99 (5): 3210–5. 2002. doi:10.1073/pnas.042699699. PMID 11867716. 
  5. ↑ "Neuronal nicotinic receptor α6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain". European Journal of Neuroscience 8 (11): 2428–2439. 1996. doi:10.1111/j.1460-9568.1996.tb01206.x. PMID 8950106. 
  6. ↑ "Involvement of α6 nicotinic receptor subunit in nicotine-elicited locomotion, demonstrated by in vivo antisense oligonucleotide infusion". NeuroReport 10 (12): 2497–2501. 1999. doi:10.1097/00001756-199908200-00012. PMID 10574359. 
  7. ↑ "Molecular model of a lattice of signalling proteins involved in bacterial chemotaxis". Nature Cell Biology 2 (11): 792–796. 2000. doi:10.1038/35041030. PMID 11056533. 
  8. ↑ Duke, T. A. J.; Le Novère, N.; Bray, D. (2001). "Conformational spread in a ring of proteins: A stochastic approach to allostery". Journal of Molecular Biology 308 (3): 541–553. doi:10.1006/jmbi.2001.4610. PMID 11327786. https://semanticscholar.org/paper/f15cb403402688d4a3fc2bf98b15027e1f85254f. 
  9. ↑ Hucka, M.; Finney, A.; Sauro, H. M.; Bolouri, H.; Doyle, J. C.; Kitano, H.; Arkin, A. P.; Bornstein, A. P. et al. (2003). "The systems biology markup language (SBML): A medium for representation and exchange of biochemical network models". Bioinformatics 19 (4): 524–531. doi:10.1093/bioinformatics/btg015. PMID 12611808. 
  10. ↑ "An allosteric model of calmodulin explains differential activation of PP2B and CaMKII". Proceedings of the National Academy of Sciences 105 (31): 10768–10773. 2008. doi:10.1073/pnas.0804672105. PMID 18669651. 
  11. ↑ "Calcium input frequency, duration and amplitude differentially modulate the relative activation of calcineurin and CaMKII". PLoS ONE 7 (9): e43810. 2012. doi:10.1371/journal.pone.0043810. PMID 22962589. 
  12. ↑ "Modulation of calmodulin lobes by different targets: an allosteric model with hemiconcerted conformational transitions". PLoS Computational Biology 11 (1): e1004063. 2015. doi:10.1371/journal.pcbi.1004063. PMID 25611683. 
  13. ↑ "The Systems Biology Graphical Notation". Nature Biotechnology 27 (8): 735–741. 2009. doi:10.1038/nbt.1558. PMID 19668183. 
  14. ↑ "Minimum Information Requested In the Annotation of biochemical Models (MIRIAM)". Nature Biotechnology 23 (12): 1509–1515. 2005. doi:10.1038/nbt1156. PMID 16333295. 
  15. ↑ "Minimum Information About a Simulation Experiment (MIASE". PLoS Computational Biology 7 (4): e1001122. 2011. doi:10.1371/journal.pcbi.1001122. PMID 21552546. 
  16. ↑ "Reproducible computational biology experiments with SED-ML - The Simulation Experiment Description Markup Language". BMC Systems Biology 5: 198. 2011. doi:10.1186/1752-0509-5-198. PMID 22172142. 
  17. ↑ "Controlled vocabularies and semantics in Systems Biology". Molecular Systems Biology 7: 543. 2011. doi:10.1038/msb.2011.77. PMID 22027554. 
  18. ↑ "BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems". Nucleic Acids Research 34 (90001): D689–D691. 2006. doi:10.1093/nar/gkj092. PMID 16381960. 
  19. ↑ "Identifiers.org and MIRIAM Registry: community resources to provide persistent identification". Nucleic Acids Research 40 (Database issue): D580–D586. 2012. doi:10.1093/nar/gkr1097. PMID 22140103. 
  20. ↑ "Scientist had abuse film of child, eight". BBC News. 4 September 2018. https://www.bbc.co.uk/news/uk-england-cambridgeshire-45408872. 
  21. ↑ Pilgrim, Tom (4 September 2018). "Top Cambridge scientist admits downloading child abuse videos". Cambridge News. https://www.cambridge-news.co.uk/news/cambridge-news/novere-babraham-court-child-sentence-15111018. 
  22. ↑ "Setting things straight". 20 September 2018. https://nlenov.wordpress.com/2018/09/20/setting-things-straight/. 

External links




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