Biology:50S ribosomal protein L25

From HandWiki
50S ribosomal subunit protein L25
1DFU L27.png
Crystal structure of e. coli ribosomal protein l25 complexed with a 5S rRNA fragment based on PDB: 1DFU​
Identifiers
OrganismEscherichia coli (strain K-12 substrain MG1655)
SymbolrplY
Entrez945618
PDB1DFU (ECOD)
UniProtP68919
Other data
Chromosomegenome: 2.28 - 2.28 Mb

50S ribosomal protein L25 is a protein that in Escherichia coli is encoded by the rplY gene.

Function

This ribosomal protein is a component of the 50S subunit. The protein binds 5S rRNA to form a stable complex. In turn 5S rRNA binds specifically to three proteins, L25, L18 and L5, forming a separate domain of the bacterial ribosome.[1] Protein L25 of E. coli is not essential for survival of the cells.[2][3]

Interactions

Ribosomal protein L25 has been shown to interact with:

References

  1. ↑ "A new method for the isolation of a 5 S RNA complex with proteins L5, L18 and L25 from Escherichia coli ribosomes". FEBS Letters 74 (2): 287–91. March 1977. doi:10.1016/0014-5793(77)80866-1. PMID 321249. 
  2. ↑ "Importance of the 5 S rRNA-binding ribosomal proteins for cell viability and translation in Escherichia coli". Journal of Molecular Biology 366 (4): 1199–208. March 2007. doi:10.1016/j.jmb.2006.11.097. PMID 17198710. 
  3. ↑ "Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection". Molecular Systems Biology 2: 2006.0008. 2006. doi:10.1038/msb4100050. PMID 16738554. 
  4. ↑ 4.0 4.1 "High resolution structure of the large ribosomal subunit from a mesophilic eubacterium". Cell 107 (5): 679–88. 2001. doi:10.1016/S0092-8674(01)00546-3. PMID 11733066. 
  5. ↑ 5.0 5.1 "Structure of the 70S ribosome complexed with mRNA and tRNA". Science 313 (5795): 1935–42. September 2006. doi:10.1126/science.1131127. PMID 16959973. Bibcode: 2006Sci...313.1935S. 
  6. ↑ 6.0 6.1 "Structures of the bacterial ribosome at 3.5 A resolution". Science 310 (5749): 827–34. November 2005. doi:10.1126/science.1117230. PMID 16272117. Bibcode: 2005Sci...310..827S. 



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