Biology:AB(O)H antigens secretion
ABH antigens secretion, i.e. presence (phenotype: secretor - Se) or absence (nonsecretor: se) of ABO blood group system antigens in saliva, milk, sweat, amniotic fluid, urine, feces and other body fluids is one of the most famous polymorphism in the field of blood antigens in body excretions. On red blood cells they are in the form of fat-soluble glycolipids, and in secretions they occur as water-soluble glycoproteins. Previous research has shown that the allele Se is completely dominant over the allele se.[1][2]
Gene function
Secretor locus is linked to the locus of Lutheran blood antigens locus were found. Parental couples with the ability to determine the secretor status of the offspring from this linkage potentially allows prenatal diagnosis of myotonic dystrophy (DM). Se locus and the Hh (FUT1) locus may be closely linked were also suggested.
Recessive phenotype distribution
The secretion of water-soluble A, B and H antigens was most widely studied in the saliva. A wide variation in the frequency of the recessive phenotype (nonsecretor: se) was registered.[3][4][5]
| Country / People | Sample (N) |
se% |
| Austria | 1,257 | 19.57 |
| Bosnia and Herzegovina | 9,521 | 23.32 |
| Brazil | ? | 19.87 |
| Canada - Sarcee Indians | 43 | 0.00 |
| Canada – Stoney Indians | 60 | 0.00 |
| Denmark | ? | 26.0 |
| Finland | 196 | 16.00 |
| Great Britain - England | ? | 25.00 |
| Great Britain - Essex | 669 | 22.80 |
| Great Britain - Liverpool | 1,118 | 22.72 |
| India – Bombay | 244 | 17.01 |
| Japan | 4,244 | 24.29 |
| Slovenia | 425 | 17.41 |
| Slovenia – Gypsies | 132 | 18.18 |
| Germany - Berlin | 363 | 22.00 |
| Polynesia – Cook Islanders | 267 | 17.20 |
| Polynesia - Kapinga Islanders | 46 | 49.00 |
| Polynesia - Maoris | 447 | 29.00 |
| US - Chinese | 218 | 20.18 |
| US - Navaho Indians | 69 | 1.45 |
| US - African American | 433 | 28.87 |
| US - Ute Indians | 79 | 0.00 |
| US - Washington (state) | 4,137 | 24.00 |
| US - Whites | 8,664 | 25.43 |
Effects
Compatibility of ABH antigens has important impacts on the prognoses of transplants of kidneys, livers and hearts, but less so on marrow, bone or cornea transplantation prognoses.[6][7]
See also
References
- ↑ Mohr, J. (1951). "Estimation of linkage between the Lutheran and the Lewis blood groups.". Acta Pathol. Microbiol. Scand. 29 (3): 339–344. doi:10.1111/j.1699-0463.1951.tb00136.x. PMID 14933035.
- ↑ Race R. R., Sanger R. (1968): Blood groups in man. F. A. Davis Co., Philadelphia.
- ↑ Boyd W. C. (1950): Genetics and the races of man. Little, Brown and Company, Boston.
- ↑ Hadziselimovic R. (1977): Genetics of the ABH antigens secretion in the population of Bosnia and Herzegovina. Yearbook, Biol. Inst., University of Sarajevo, 30: 29-104.
- ↑ Cavalli-Sforza L. L., Bodmer W. F. (1999): The genetics of human populations. Dover Publications, Inc., Mineola, New York, ISBN:0-486-40693-8.
- ↑ Rouger P (Nov 2005). "Impact of blood group antigens in transplantation". Transfus Clin Biol. 12 (5): 403–8. doi:10.1016/j.tracli.2005.11.002. PMID 16330233.
- ↑ Galili, U. (Aug 2006). "Xenotransplantation and ABO incompatible transplantation: the similarities they share". Transfus Apher Sci. 35 (1): 45–58. doi:10.1016/j.transci.2006.05.007. PMID 16905361.
External links
- ISBT Table of blood group antigens within systems.
- BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH.
- Blood Groups and Red Cell Antigens National Center for Biotechnology Information (NCBI).
- Distribution of Blood Types, Behavioral Sciences Department, Palomar College.
- Blood group antigen protein
- ISBT Table of blood group antigens within systems.
- BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH.
- Blood Groups and Red Cell Antigens National Center for Biotechnology Information (NCBI).
- Distribution of Blood Types, Behavioral Sciences Department, Palomar College.
- Blood group antigen protein
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