Biology:ACTG2
 Generic protein structure example |
Actin, gamma-enteric smooth muscle is a protein that in humans is encoded by the ACTG2 gene.[1][2][3]
Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 2, encoded by this gene, is a smooth muscle actin found in enteric tissues.[3]
Interactions
ACTG2 has been shown to interact with Emerin.[4]
References
- ↑ "Structure, chromosome location, and expression of the human smooth muscle (enteric type) gamma-actin gene: evolution of six human actin genes". Mol Cell Biol 11 (6): 3296–306. July 1991. doi:10.1128/mcb.11.6.3296. PMID 1710027.
- ↑ Ueyama H (May 1991). "A HindIII DNA polymorphism in the human enteric type smooth muscle actin gene (ACTSG)". Nucleic Acids Res 19 (2): 411. doi:10.1093/nar/19.2.411. PMID 1673027.
- ↑ 3.0 3.1 "Entrez Gene: ACTG2 actin, gamma 2, smooth muscle, enteric". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=72.
- ↑ Lattanzi, Giovanna; Cenni Vittoria; Marmiroli Sandra; Capanni Cristina; Mattioli Elisabetta; Merlini Luciano; Squarzoni Stefano; Maraldi Nadir Mario (April 2003). "Association of emerin with nuclear and cytoplasmic actin is regulated in differentiating myoblasts". Biochem. Biophys. Res. Commun. (United States) 303 (3): 764–70. doi:10.1016/S0006-291X(03)00415-7. ISSN 0006-291X. PMID 12670476.
External links
- Human ACTG2 genome location and ACTG2 gene details page in the UCSC Genome Browser.
Further reading
- "The cleavage of host cell proteins by HIV-1 protease". Folia Biol. (Praha) 42 (5): 227–30. 1997. doi:10.1007/BF02818986. PMID 8997639.
- "HIV-1 protease cleaves actin during acute infection of human T-lymphocytes". AIDS Res. Hum. Retroviruses 8 (2): 291–5. 1992. doi:10.1089/aid.1992.8.291. PMID 1540415. https://zenodo.org/record/1235231.
- "Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus". J. Biol. Chem. 266 (22): 14548–53. 1991. doi:10.1016/S0021-9258(18)98721-1. PMID 1907279.
- "Non-viral cellular substrates for human immunodeficiency virus type 1 protease". FEBS Lett. 278 (2): 199–203. 1991. doi:10.1016/0014-5793(91)80116-K. PMID 1991513.
- "The nucleotide sequence of a human smooth muscle (enteric type) gamma-actin cDNA". Nucleic Acids Res. 18 (14): 4263. 1990. doi:10.1093/nar/18.14.4263. PMID 2377475.
- "Chromosomal mapping of the human smooth muscle actin gene (enteric type, ACTA3) to 2p13.1 and molecular nature of the hindIII polymorphism". Genomics 25 (3): 720–3. 1995. doi:10.1016/0888-7543(95)80016-F. PMID 7759108.
- "Cloning and sequence analysis of the mouse smooth muscle gamma-enteric actin gene". Genomics 28 (2): 154–62. 1996. doi:10.1006/geno.1995.1126. PMID 8530021.
- "Establishment of a Functional Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcription Complex Involves the Cytoskeleton". J. Exp. Med. 188 (11): 2113–25. 1999. doi:10.1084/jem.188.11.2113. PMID 9841925.
- "Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF". Curr. Biol. 9 (21): 1271–4. 1999. doi:10.1016/S0960-9822(99)80511-9. PMID 10556093.
- "Spatially regulated differentiation of endometrial vascular smooth muscle cells". Hum. Reprod. 15 (2): 284–92. 2000. doi:10.1093/humrep/15.2.284. PMID 10655297.
- "The smooth muscle gamma-actin gene is androgen responsive in prostate epithelia". Gene Expr. 10 (5–6): 201–11. 2003. doi:10.3727/000000002783992424. PMID 12450213.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "RNA Polymerase II Accumulation in the Promoter-Proximal Region of the Dihydrofolate Reductase and γ-Actin Genes". Mol. Cell. Biol. 23 (6): 1961–7. 2003. doi:10.1128/MCB.23.6.1961-1967.2003. PMID 12612070.
- "Human Immunodeficiency Virus Type 1 Tat Regulates Endothelial Cell Actin Cytoskeletal Dynamics through PAK1 Activation and Oxidant Production". J. Virol. 78 (2): 779–89. 2004. doi:10.1128/JVI.78.2.779-789.2004. PMID 14694110.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. 2005. doi:10.1038/nature03466. PMID 15815621. Bibcode: 2005Natur.434..724H.
PDB gallery | |
|---|---|
|
 |  |
