Biology:APPBP2
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 Generic protein structure example |
Amyloid protein-binding protein 2 is a protein that in humans is encoded by the APPBP2 gene.[1][2]
The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. This gene has been found to be highly expressed in breast cancer. Multiple polyadenylation sites have been found for this gene.[2]
Interactions
APPBP2 has been shown to interact with Amyloid precursor protein.[1]{
References
- ↑ 1.0 1.1 "PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein". Proc Natl Acad Sci U S A 95 (25): 14745–50. Jan 1999. doi:10.1073/pnas.95.25.14745. PMID 9843960.
- ↑ 2.0 2.1 "Entrez Gene: APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10513.
External links
- Human APPBP2 genome location and APPBP2 gene details page in the UCSC Genome Browser.
Further reading
- "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. 1997. doi:10.1093/dnares/3.5.321. PMID 9039502.
- "Multiple genes at 17q23 undergo amplification and overexpression in breast cancer.". Cancer Res. 60 (19): 5340–4. 2000. PMID 11034067.
- "Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer.". Proc. Natl. Acad. Sci. U.S.A. 98 (10): 5711–6. 2001. doi:10.1073/pnas.091582298. PMID 11331760. Bibcode: 2001PNAS...98.5711M.
- "The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 14979–84. 2002. doi:10.1073/pnas.261463298. PMID 11742091.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Association of the herpes simplex virus type 1 Us11 gene product with the cellular kinesin light-chain-related protein PAT1 results in the redistribution of both polypeptides.". J. Virol. 77 (17): 9192–203. 2003. doi:10.1128/JVI.77.17.9192-9203.2003. PMID 12915535.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
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