Biology:ARHGEF9
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene.[1][2][3]
Function
ARHGEF9 belongs to a family of Rho-like GTPases that act as molecular switches by cycling from the active GTP-bound state to the inactive GDP-bound state. These proteins are key regulators of the actin cytoskeleton and are involved in cell signaling.[supplied by OMIM][3]
Interactions
ARHGEF9 has been shown to interact with GPHN[4] and SMURF1.[5]
References
- ↑ "Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42". J Biol Chem 274 (47): 33587–93. Dec 1999. doi:10.1074/jbc.274.47.33587. PMID 10559246.
- ↑ "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res 4 (5): 307–13. Feb 1998. doi:10.1093/dnares/4.5.307. PMID 9455477.
- ↑ 3.0 3.1 "Entrez Gene: ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23229.
- ↑ "Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin". Nat. Neurosci. 3 (1): 22–9. 2000. doi:10.1038/71096. PMID 10607391.
- ↑ "Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway". Biol. Chem. 389 (4): 405–13. Apr 2008. doi:10.1515/BC.2008.036. PMID 18208356.
External links
- Human ARHGEF9 genome location and ARHGEF9 gene details page in the UCSC Genome Browser.
Further reading
- "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. 2004. doi:10.1101/gr.2435604. PMID 15342556.
- "The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering". J. Neurosci. 24 (25): 5816–26. 2004. doi:10.1523/JNEUROSCI.1184-04.2004. PMID 15215304. PMC 6729214. http://discovery.ucl.ac.uk/9558/1/9558.pdf.
- "Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin". Biol. Chem. 382 (10): 1455–62. 2002. doi:10.1515/BC.2001.179. PMID 11727829.
- "Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin". Nat. Neurosci. 3 (1): 22–9. 2000. doi:10.1038/71096. PMID 10607391.
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