Biology:ARL1

Generic protein structure example

ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1 gene.

Function

The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.

Interactions

ARL1 has been shown to interact with GOLGA4 and GOLGA1.

External links

• Human ARL1 genome location and ARL1 gene details page in the UCSC Genome Browser.

Further reading

• "Different ARF domains are required for the activation of cholera toxin and phospholipase D". J. Biol. Chem. 270 (1): 21–4. 1995. doi:10.1074/jbc.270.1.21. PMID 7814376. 
• "Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1)". J. Biol. Chem. 273 (25): 15872–6. 1998. doi:10.1074/jbc.273.25.15872. PMID 9624189. 
• "GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23". J. Biol. Chem. 274 (20): 14198–203. 1999. doi:10.1074/jbc.274.20.14198. PMID 10318838. 
• "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. 2000. doi:10.1101/gr.143000. PMID 11076863. 
• "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. 2001. doi:10.1101/gr.GR1547R. PMID 11230166. 
• "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. 2000. doi:10.1093/embo-reports/kvd058. PMID 11256614. 
• "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins". J. Biol. Chem. 276 (25): 22826–37. 2001. doi:10.1074/jbc.M102359200. PMID 11303027. 
• "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Mol. Biol. Cell 14 (9): 3767–81. 2003. doi:10.1091/mbc.E03-01-0864. PMID 12972563. 
• "Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network". Mol. Biol. Cell 15 (10): 4426–43. 2004. doi:10.1091/mbc.E03-12-0872. PMID 15269279. 
• "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. 2004. doi:10.1101/gr.2576704. PMID 15489336. 
• "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415-8. 2006. doi:10.1093/nar/gkj139. PMID 16381901. 
• "Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells". Mol. Membr. Biol. 23 (6): 475–85. 2007. doi:10.1080/09687860600840100. PMID 17127620. 
• "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.