Biology:ASB2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Ankyrin repeat and SOCS box protein 2 is a protein that in humans is encoded by the ASB2 gene.

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.

External links

• Human ASB2 genome location and ASB2 gene details page in the UCSC Genome Browser.

Further reading

• "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235–41. 2002. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535. 
• "Twenty proteins containing a C-terminal SOCS box form five structural classes.". Proc. Natl. Acad. Sci. U.S.A. 95 (1): 114–9. 1998. doi:10.1073/pnas.95.1.114. PMID 9419338. Bibcode: 1998PNAS...95..114H. 
• "Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4.". Gene 258 (1–2): 31–41. 2001. doi:10.1016/S0378-1119(00)00402-9. PMID 11111040. 
• "Functional analysis of Asb-1 using genetic modification in mice". Mol. Cell. Biol. 21 (18): 6189–97. 2001. doi:10.1128/MCB.21.18.6189-6197.2001. PMID 11509662. 
• "ATRA-regulated Asb-2 gene induced in differentiation of HL-60 leukemia cells". FEBS Lett. 505 (2): 223–8. 2001. doi:10.1016/S0014-5793(01)02829-0. PMID 11566180. 
• "ASB-2 inhibits growth and promotes commitment in myeloid leukemia cells". J. Biol. Chem. 277 (1): 218–24. 2002. doi:10.1074/jbc.M108476200. PMID 11682484. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1". Mamm. Genome 15 (3): 162–78. 2004. doi:10.1007/s00335-003-2311-y. PMID 15014966. 
• "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "ASB2 is an Elongin BC-interacting protein that can assemble with Cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex". J. Biol. Chem. 280 (7): 5468–74. 2005. doi:10.1074/jbc.M413040200. PMID 15590664. 
• "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
• "ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes". FEBS Lett. 579 (30): 6796–802. 2006. doi:10.1016/j.febslet.2005.11.016. PMID 16325183.