Biology:Alternative ribosome-rescue factor B
From HandWiki
| Peptidyl-tRNA hydrolase ArfB | |||||||
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| Symbol | ArfB | ||||||
| UniProt | P40711 | ||||||
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Alternative ribosome-rescue factor B (ArfB, YaeJ) also known as peptidyl-tRNA hydrolase,[1] is a protein that plays a role in rescuing of stalled ribosomes.[1] It works like a GGQ-release factor itself, releasing the peptide from tRNA.[2] At the same time, it fits into the mRNA tunnel to remove the mRNA.[3]
This gene is also found in eukaryotic organelles as MRPL58 (ICT1). The similarity is high enough to be interchangeable.[4] Its role has expanded to that of a codon-independent release factor, although it likely still functions in ribosomal rescue.[5]
See also
References
- ↑ 1.0 1.1 "Peptidyl-tRNA hydrolase, ribosome rescue factor". BioCyc. SRI International. http://biocyc.org/ECOLI/NEW-IMAGE?type=ENZYME&object=EG12354-MONOMER.
- ↑ "Mechanism of ribosome rescue by alternative ribosome-rescue factor B". Nature Communications 11 (1): 4106. August 2020. doi:10.1038/s41467-020-17853-7. PMID 32796827. Bibcode: 2020NatCo..11.4106C.
- ↑ "ArfB can displace mRNA to rescue stalled ribosomes". Nature Communications 11 (1): 5552. November 2020. doi:10.1038/s41467-020-19370-z. PMID 33144582. Bibcode: 2020NatCo..11.5552C.
- ↑ "Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria". PLOS Genetics 12 (3): e1005964. March 2016. doi:10.1371/journal.pgen.1005964. PMID 27029019.
- ↑ "A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome". The EMBO Journal 29 (6): 1116–1125. March 2010. doi:10.1038/emboj.2010.14. PMID 20186120.
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